Advertisement

Nutrition Intervention Studies of the Esophageal Cancer in Linxian, China

  • Jun-Yao Li
Chapter
Part of the Experimental Biology and Medicine, Vol. 10 book series (EBAM, volume 10)

Abstract

The highest worldwide incidence and mortality for cancer of the esophagus occurs in China.(1,2) Linxian, in Henan Province, is the epicenter of this maligancy and may indeed be the world’s highest risk area, where the cumulative death rates (0–74yr) are 32.5% for males and 20.4% for females. Reasons for such exceptional risk of esophageal cancer are not yet known, but a series of investigations carried out in Linxian suggests that the population may be enhanced susceptibility to specific carcinogens because of deficiencies of multiple nutrients, especially vitamins and minerals. (3,4,5) To test an hypothesis that multiple vitamin/mineral deficiencies may contribute to Linxian’ s high rates and that supplementation may reduce the cancer risk, the Cancer Institute, Chinese Academy of Medical Sciences in collaboration with the National Cancer Institute, NIH, in U.S.A. are carring out two intervention trials in Linxian using multiple vitamin-mineral supplements. One trial will be conducted in patients diagnosed with esophageal dysplasia and the other in the general population.

Keywords

Esophageal Cancer Intervention Trial Severe Dysplasia Barefoot Doctor Vitamin Tablet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Li Jun-Yao: Epidemiology of Esophageal Cancer in China. Natl Cancer Inst Monogr 62:113–120, 1982.Google Scholar
  2. 2.
    Yang CS: Research on esophageal cancer in China: a review. Cancer Res 40: 2633–2644, 198O.PubMedGoogle Scholar
  3. 3.
    Zheng SF: Copper, iron, magnesium, and zinc contents in hair of peasants in high and low incidence areas of esophageal cancer. Chin J Oncol 4: 174–177, 1982.Google Scholar
  4. 4.
    Yang CS, etal:Diet and Vitamin nutrition of the high esophageal cancer risk population in Linxian, China. Nutr.Cancer 4: 154–164, 1982.CrossRefGoogle Scholar
  5. 5.
    Yang CS, etal: Nutritional Status of the high esophageal cancer risk population in Linxian, China: effects of vitamin supplementation and seasonal variations. Presented at the 4th Symposium on Epidemiology and Cancer Registries in the Pacific Basin, Kona, Hawaii. January 15–20, 1984.Google Scholar
  6. 6.
    Li JY, etal: Atlas of Cancer mortality in the People’s Republic of China-An aid for cancer control and research. Int. J. Epid. 10: 127–133, 1981.CrossRefGoogle Scholar
  7. 7.
    Li JY, etal:Atlas of cancer mortality in the People’s Republic of China. The China Map Press, Peking, 1981.Google Scholar
  8. 8.
    Li JY Investigation of geographic patterns for cancer mortality in China. Natl. Cancer Inst Monogo. 62:17–42, 1981.Google Scholar
  9. 9.
    Munoz N. Crespi M. Grassi A. Wang GQ, Shen Q, Li ZC: Precursor lesions of esophageal cancer risk population in Linxian China. Lancet 1: 876–879, 1982.PubMedCrossRefGoogle Scholar
  10. 10.
    Van Hensburg ST: Epidemiology and dietary evi dence for a specific nutritional predisposition to esophageal cancer. J Natl Cancer Inst. 67:243–251, 1981.Google Scholar
  11. 11.
    International Agency for Research on Cancer: Final report: Etiology of esophageal cancer in Caspian littoral of Iran. Lyon. IARC, 1981.Google Scholar
  12. 12.
    Mettlin C, Graham S, Priore R, Marshall J, Swanson M:Diet and cancer of the esophagus. Nutr. Cancer 2: 143–147, 1980.CrossRefGoogle Scholar
  13. 13.
    Sporn MB, Newton DL:Chemoprevention of cancer with retinoids. Fed Proc 38: 2528–2534, 1979.PubMedGoogle Scholar
  14. 14.
    Peto R, Doll R, Buckley JD, Sporn MB: Can di etary beta-carotene materially reduce human cancer rates. Nature 29O: 201–208, 1981.CrossRefGoogle Scholar
  15. 15.
    Foy H, Mbaya V: Riboflavin. Prog Fd Nutr Sci 2: 357–394, 1977.Google Scholar
  16. 16.
    Shamberger RJ: Vitamins and Cancer: Current controversies. Cancer Bull 34:150–154, 1982.Google Scholar
  17. 17.
    Shaklar G: Oral mucosal carcinogenesis in hams ters: inhibition by vitamin E. J Natl Cancer Inst 68:791–797, 1982.Google Scholar
  18. 18.
    Blondell JM: The anticarcinogenic effect of Magnesium. Med Nypoth 6: 863–871, 1980.CrossRefGoogle Scholar
  19. 19.
    Luo XM, Wei MJ, Yang SP: Inhibitory effects of Molybdenum on esophageal and forestomach carcinogenesis in rats. J Natl Cancer Inst. 71:75–80, 1983.PubMedGoogle Scholar
  20. 20.
    Medina D: Selenium and murine mammary tumori-genesis. Cancer Bull 34:162–164, 1982.Google Scholar
  21. 21.
    Fong LY, Sivak A, Newberne PM: Zinc deficiency and methlybenzylnitrosamine-induced esophageal cancer in rats. J Natl Cancer Inst 61:145–150, 1978.PubMedGoogle Scholar
  22. 22.
    Ershow AG, etal: Compliance and nutritional status response during a feasibility study for an intervention trial in China, (in press)Google Scholar
  23. 23.
    Li JY, etal: A pilot vitamin intervention trial in Linxian.Presented at Hawaii conference, 1984. (see ref.5)Google Scholar
  24. 24.
    Blot WJ, Li JY: Some considerations in the design of a nutrition intervention trial in Linxian, China. Presented at Hawaii conference, 1984(see ref.5)Google Scholar
  25. 25.
    Rothman KJ, Boice JD: Epidemiologic analysis with the programmable calculator, NIH Publication No. 79–1649, 1979.Google Scholar

Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Jun-Yao Li
    • 1
  1. 1.Department of EpidemiologyCancer Institute, Chinese Academy of Medical SciencesUSA

Personalised recommendations