Abstract
Clinical trials are widely used and accepted as the best method to evaluate the effect of therapy or prophylactic interventions. The design of cancer prevention trials are based on the same principles as cancer therapy trials (Peto, et al, 1976). However, there are a number of important differences in the methodology, logistics and costs of prevention trials as contrasted to therapy trials. A clear recognition and careful consideration of such differences provide a better study design resulting in improved evaluation of cancer prophylactic interventions.
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Haynes, R.B., et al: Patient Compliance to Prescribed Antihypertensive Medication Regimens: A Report to the National Heart, Lung and Blood Institute, U.S. Dept. of Health and Human Services, NIH, Publication No. 81–2101, October, 1980.
Magnus, K. and Miller, A.B.: Controlled Prophylactic Trials in Cancer. JNCI, Vol. 64, No. 4, 693–699, 1980.
Peto, R., Pike, M.C., Armitage, P., Breslow, N.E., Cox, D.R., Howard, S.V., Mantel, N., McPherson, K., Peto, J. and Smith, P.G.: Design and Analysis of Randomized Clinical Trials Requiring Prolonged Observation of Each Patient, I. Introduction and Design. Brit. J. of Cancer, 34:585–612, 1976.
Staquet, M.: Critical Evaluation of Clinical Trials in Oncology. Current Concepts in Oncology, 17–22, Winter, 1984.
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© 1986 The Humana Press Inc.
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Moon, T.E., Rodney, S.R., Peng, YM., Alberts, D.S., Meyskens, F. (1986). Design and Compliance Considerations of Dietary Intervention Trials. In: Meyskens, F.L., Prasad, K.N. (eds) Vitamins and Cancer. Experimental Biology and Medicine, Vol. 10, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-5006-7_17
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DOI: https://doi.org/10.1007/978-1-4612-5006-7_17
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9395-8
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