Abstract
It is generally accepted that class II molecules are in fact Ir gene products. From a multitude of studies which began over a decade ago it can now be argued that class II molecules are somehow involved in controlling or influencing the specificity of T-cell recognition. Remaining unclear, however, is the relationship between T-cell specificity and function. That is, the question of whether particular class II gene products determine discrete immunological functions such as help or suppression has yet to be answered. Because experimental work in the mouse has so profoundly influenced immunological concepts applied to man, I would like to present first a brief overview of our current understanding of murine and human Ir gene function before framing an alternative hypothesis regarding the functional control of the human immune system by class II molecules.
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References
Mevitt HO and Chinitz A. Science 163:1207 (1969).
Mevitt HO et al. J Exp Med 135:1259 (1972).
Dorf ME and Benacerraf B. PNAS 72:3671 (1975).
Cullen SE et al. PNAS 71:648 (1974).
Rosenthal AS and Shevach EM. J Exp Med 138:1194 (1973).
Shevach EM and Rosenthal AS. J Exp Med 138:1213 (1973).
Berzofsky JA. In: Biological Regulation and Development, vol 2, Plenum Press, New York. RF Goldberger, ed., p 467, (1980).
Benacerraf B. J Immunol 120:1809 (1978).
Rosenthal AS. Immunol Rev 40:135 (1978).
von Boehmer H, Haas W and Jerne N. PNAS (USA) 75:2439 (1978).
Zinkernagle RM et al. Nature 271:251 (1978).
Miller JFAP et al. Scand J Immunol 9:29 (1979).
Schwartz RH. Scand J Immunol 7:3 (1978).
Ishii N et al. J Exp Med 154:978 (1981).
Thomas DW and Hoffman MD. J Immunol 128:780 (1982).
Clark RB and Shevach EM. J Exp Med 155:635 (1982).
Kimoto M, Krenz TJ and Fathman CG. J Exp Med 154:883 (1981).
Ishii N, Nagy Z and Klein J. J Exp Med 157:998 (1983).
Thomas DW et al. J Exp Med 152:620 (1980).
Thomas DW et al. J Exp Med 153:583 (1981).
Heber-Katz E et al. J Exp Med 155:1086 (1982).
Schwartz RH. 5th Int Congress of Immunology, Kyoto, Japan (1983).
Werdelin O. J Immunol 129:1883 (1982).
Rock KL and Benacerraf B. J Exp Med 157:1618 (1983).
Fathman CG and Frelinger JG. Ann Rev Immunol 1:633 (1983).
Frelinger JG et al. J Exp Med 159:704 (1984).
Baxevanis CN, Nagy Z and Klein J. J Immunol 131:628 (1983).
Mawas C et al. Human Immunology 8:1 (1983).
Hurley CK, Giles RC and Capra JD. Immunology Today 8:219 (1983).
Eckels DD and Hartzman RJ. Immunogenetics 16:117 (1982).
Eckels DD and Hartzman RJ. Human Immunology 3:337 (1981).
Eckels DD et al. In: Ir genes, past, present, and future, Human Press, Clifton NJ. Pierce CW et al., eds., p 535 (1983).
Zeevi A et al. Human Immunology 6:97 (1983).
Pawelec G and Wernet P. Immunogenetics 11:507 (1980).
Reinsmoen NL and Bach FH. Human Immunology 4:249 (1982).
Eckels DD et al. Human Immunology 4:313 (1982).
Lamb JR et al. J Immunol 128:233 (1982).
Eckels DD et al. Nature 301:716 (1983).
Qvigstad E, Digranes S and Thorsby E. Scand J Immunol (in press).
Lamb JR et al. Nature 300:66 (1982).
Eckels DD et al. Immunogenetics 19:409 (1984).
Zeevi A and Duquesnoy R. J Immunogenetics (in press).
Lamb JR et al. Immunology 50:397 (1983).
Jacobson S et al. 5th Int Congress of Immunology, Kyoto, Japan (1983).
Lamb JR et al. J Immunol 129:1465 (1982).
Meuer SC et al. J Immunol 131:1167 (1983).
Goodman JW and Sercarz EE. Ann Rev Immunol 1:465 (1983).
Festenstein H. personal communication.
Lamb JR et al. J Exp Med 157:1434 (1983).
Zanders ED et al. Nature 303:625 (1983).
Lamb JR and Feldmann M. Nature 308:72 (1984).
Nikaein A et al. Immunobiology 166:190 (1984).
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Eckels, D.D. (1985). Recognition of HLA class II Molecules by Functional Human T-Lymphocyte Clones (TLC’s). In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_7
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_7
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