Abstract
Human T cells which recognize class II major histocompatibility complex (MHC) antigens are almost exclusively contained within a subpopulation of T cells that bear the T4 (Leu 3) cell surface marker1–3. Antibodies that bind the T4 molecule have been shown to block the proliferative and cytotoxic responses of T4+ cells to class II MHC antigens2,3,4. Studies that have partitioned the cytolytic process into binding and post-binding phases have demonstrated that anti-T4 antibodies block cytolysis by interfering with formation of functional conjugates6,7. These and other findings have led to the hypothesis that the function of the T4 molecule is to bind to a non-polymorphic epitope on class II molecules and to thereby act as an ancillary structure that can facilitate T cell-target cell interactions2, 6, 8.
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Biddison, W.E., Shaw, S. (1985). SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-T3 and Anti-T4 Antibodies. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_6
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_6
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