Molecular Studies of the Human T-Cell Antigen Receptor

  • Mary K. L. Collins
  • A. Maija Kissonerghis
  • M. Jenny Dunne
  • Michael J. Owen
Part of the Experimental Biology and Medicine book series (EBAM, volume 9)


The T cell receptor for antigen has been identified in both mouse and man as a 90-kd disulphide-linked heterodimer comprised of one α chain (~ 50,000 mol.wt.) and one β chain (~ 40,000 mol.wt.) (1–3). Recently, cDNA clones encoding one of the chains of the T-cell antigen receptor have been isolated from mouse (4) and human (5) T-cell libraries. Sequence analysis of these cDNA clones demonstrates that they contain variable, joining and constant regions similar to those encoding immunoglobulins (5,6). Furthermore, the cDNA clones hybridise to gene sequences capable of undergoing somatic rearrangements in T-cells (4). The mouse and human cDNA probes most probably detect the β chain family of the T-cell antigen receptor since partial protein sequence analysis of a human T-cell β chain agrees with the translated nucleotide sequence of the human cDNA clone (7).


Somatic Rearrangement Translate Nucleotide Sequence Human cDNA Probe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Mary K. L. Collins
    • 1
  • A. Maija Kissonerghis
    • 1
  • M. Jenny Dunne
    • 1
  • Michael J. Owen
    • 1
  1. 1.Imperial Cancer Research Fund Tumour Immunology Unit, Department of ZoologyUniversity College LondonLondonUK

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