Abstract
The ability to dissect immune parameters in situ by immunohistology and in vitro by a variety of assays has resulted in an increasing awareness of the complexity of the host-tumour relationship. The correlation in some tumours between infiltration by leukocytes and prognosis offered preliminaryindications of the effectiveness of the anti-tumour response (1,2). More recently, it has been possible by staining of sections to show the presence of macrophages, T helper and T cytotoxic/suppressor cells and B lymphocytes in a wide range of tumours using specific monoclonal antibodies. In addition, several groups have been able to purify T lymphocytes and macrophages from the tumour and demonstrate proliferative and cytotoxic activity against autologous tumour cells (reviewed in 3).
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Vose, B.M. (1985). T Cell Clones Recognising Autologous Tumour Cells. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_37
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_37
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