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The IL-1 Pathway in T Cell Activation

  • Chapter
Human T Cell Clones

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 9))

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Abstract

Almost without exception, normal T cells or their progeny require accessory cells (AC) or their products for activation and proliferation induced by mitogens, antigens and soluble anti-idiotypic antibodies. Despite many years of effort, the role of MHC products, interleukin-1 (IL-1) and other possible signalling systems of AC which promote T cell responses remain unclear. In this report we discuss a new IL-l-dependent human T cell activation system which contrasts with and illuminates properties of T cell activation pathways regulated by AC. The results show that IL-1 can promote IL-2 receptor expression on T cells and that signals other than IL-1 are required for T cell responses to lectin mitogens.

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Author information

Authors and Affiliations

  1. Lombardi Center, Georgetown University, 20007, Washington, DC, USA

    Phil Lake, Eve D. Robinson, Mark Brunswick, Lex Cowsert & Tran C. Chanh

Authors
  1. Phil Lake
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  2. Eve D. Robinson
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  3. Mark Brunswick
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  4. Lex Cowsert
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  5. Tran C. Chanh
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Editor information

Editors and Affiliations

  1. Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK

    Marc Feldmann

  2. MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK

    Jonathan R. Lamb

  3. Tissue Bank, Naval Medical Research Institute, Bethesda, Maryland, USA

    James N. Woody

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© 1985 The Humana Press Inc.

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Lake, P., Robinson, E.D., Brunswick, M., Cowsert, L., Chanh, T.C. (1985). The IL-1 Pathway in T Cell Activation. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_36

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  • DOI: https://doi.org/10.1007/978-1-4612-4998-6_36

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9391-0

  • Online ISBN: 978-1-4612-4998-6

  • eBook Packages: Springer Book Archive

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