Abstract
The mechanism by which antigen-specific T helper cells convey information to their B cell counterparts has received much attention in the immunologic literature. Recent studies with cloned T helper cells indicate that antigen-specific T helper factors (THF), capable of inducing specific antibody responses, are actively secreted in response to antigenic restimulation. Serologic analysis of such factors suggest the presence of constant and variable regions, as well as products of class II histocompatibility genes. Current models suggest that THF represents the secreted variant form of the T cell receptor.
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Woody, J.N., Lamb, J.R., Zanders, E.D., Feldman, M. (1985). Antigen-Specific T Cell Helper Factors. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_33
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_33
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