Accessory Cell Requirements for the Proliferation of Antigen Specific Human T Cells

  • Raif S. Geha
Part of the Experimental Biology and Medicine book series (EBAM, volume 9)


The availability of antigen specific human T cell clones has provided the tools to investigate the mechanisms of triggering activated T cells by antigen. In this review we will show that several types of cells e.g. monocytes, B cell lines and fibroblasts can trigger antigen specific proliferation of human T cell clones. The requirements for this triggering differ from those of freshly isolated human peripheral blood T cells particularly in regard to interleukin-1. The results presented suggest that whereas several cell types can successfully present antigen to a previously activated T cell, only certain cells such as monocytes/macrophages may be.


Cell Clone Cell Blast Tetanus Toxoid Accessory Cell Diphtheria Toxoid 
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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Raif S. Geha
    • 1
  1. 1.Depart. of PediatricsHarvard Medical SchoolBostonUSA

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