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Accessory Cell Requirements for the Proliferation of Antigen Specific Human T Cells

  • Raif S. Geha
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 9)

Abstract

The availability of antigen specific human T cell clones has provided the tools to investigate the mechanisms of triggering activated T cells by antigen. In this review we will show that several types of cells e.g. monocytes, B cell lines and fibroblasts can trigger antigen specific proliferation of human T cell clones. The requirements for this triggering differ from those of freshly isolated human peripheral blood T cells particularly in regard to interleukin-1. The results presented suggest that whereas several cell types can successfully present antigen to a previously activated T cell, only certain cells such as monocytes/macrophages may be.

Keywords

Cell Clone Cell Blast Tetanus Toxoid Accessory Cell Diphtheria Toxoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Raif S. Geha
    • 1
  1. 1.Depart. of PediatricsHarvard Medical SchoolBostonUSA

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