Accessory Cell Requirements for the Proliferation of Antigen Specific Human T Cells
The availability of antigen specific human T cell clones has provided the tools to investigate the mechanisms of triggering activated T cells by antigen. In this review we will show that several types of cells e.g. monocytes, B cell lines and fibroblasts can trigger antigen specific proliferation of human T cell clones. The requirements for this triggering differ from those of freshly isolated human peripheral blood T cells particularly in regard to interleukin-1. The results presented suggest that whereas several cell types can successfully present antigen to a previously activated T cell, only certain cells such as monocytes/macrophages may be.
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