Abstract
It is clear that in man, just as in the mouse, virus-specific cytotoxic T cells are genetically restricted in their function, recognising a viral target antigen on the surface of infected cells not as an isolated structure but in some form of association with the polymorphic determinants of HLA class I gene products (1–3). Thus virus-specific cytotoxic T cells offer a means of probing HLA class I antigen polymorphism which is independent of that provided by allo-specific cytotoxic T cells raised in mixed lymphocyte cultures or of that afforded by serological reagents. There is now growing evidence to suggest that a divergence exists between serologically-defined and T cell-defined polymorphisms (4–7). However, relatively little is known about the relationship between those sites on HLA class I molecules recognized by virus-specific cytotoxic T cells and those recognised by allospecific cytotoxic T cells. The work reported here, seeking to distinguish between T cell restricting determinants and allo-specific T cell recognition sites on HLA class I molecules, has taken advantage of the fact that Epstein-Barr (EB) virus-transformed B cells can act as in vitro stimulators of either of EB virus-specific cytotoxic T cells (showing classical HLA class I antigen restriction) or of allo-specific cytotoxic T cells (directed against foreign HLA class I antigens) depending upon the particular in vitro responder: stimulator combination employed (8,9).
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Wallace, L.E., Houghton, M.A., Rickinson, A.B. (1985). HLA-Class I Antigen Recognition by EB Virus-Specific and Allo-Specific Cytotoxic T Cells. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_10
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_10
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