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Functional Aspects of Accessory Cell Heterogeneity

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Immune Regulation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 8))

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Abstract

The activation of T cells requires the participation of Ia+ accessory cells (AC) (1–4). Originally, macrophages (Mph) were identified as AC (1,2) but soon, their role as unique AC was challenged by the detection of other, non-Mph cell types which also expressed AC function (5–14). In the meantime, it has been established that all Ia+ cells, be they macrophages or not, can function as AC (1–19). Although this clearly demonstrates AC heterogeneity, the question has not been answered whether any AC type can activate all or only certain T cell functions, ie. whether functional heterogeneity exists.

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Author information

Authors and Affiliations

  1. Institute for Microbiology, University of Basel, Petersplatz 10, CH-4003, Basel, Switzerland

    Erb P. Ramila, GI Sklenar & M. Kennedy

Authors
  1. Erb P. Ramila
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  2. GI Sklenar
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  3. M. Kennedy
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Editor information

Editors and Affiliations

  1. Middlesex Hospital Medical School, London, UK

    Marc Feldmann

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© 1985 The Humana Press Inc.

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Ramila, E.P., Sklenar, G., Kennedy, M. (1985). Functional Aspects of Accessory Cell Heterogeneity. In: Feldmann, M., Mitchison, N.A. (eds) Immune Regulation. Experimental Biology and Medicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4996-2_38

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  • DOI: https://doi.org/10.1007/978-1-4612-4996-2_38

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9390-3

  • Online ISBN: 978-1-4612-4996-2

  • eBook Packages: Springer Book Archive

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