Peptides as Potential Vaccines Against Foot and Mouth Disease
Synthetic peptides corresponding to the immunogenic site of foot-and-mouth disease virus elicit levels of neutralizing antibody which can protect experimental animals and cattle against challenge infection with high levels of virus. This has allowed us to study the chemical basis for antigenic variation which is a major problem in controlling the disease by vaccination. Comparison of the sequences of the immunogenic sites of viruses belonging to different serotypes and subtypes shows that single amino acid changes in the immunogenic site can alter the antigenic spectrum of the virus. Moreover peptides with appropriate amino acid substitutions have been made which have a wider antigenic spectrum than peptides with the “natural” sequence. Combining this approach with molecular modelling should allow the “tailoring” of peptide vaccines with more useful antigenic characteristics.
KeywordsFormaldehyde Polypeptide Trypsin
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