Abstract
Until recently, it was generally assumed that cell surface structures other than antigen-specific receptors were not involved in T cell function. However, the reports in 1979 by Nakayama et al.1 and Shinohara and Sachs2 that antibodies to the Lyt-2/3 antigenic complex inhibited the specific cytolytic activity of murine cytolytic T lymphocytes (CTL) suggested that differentiation antigens expressed on the surface membrane of T cells may have functional importance in T cell immune responses. Since these early reports, a great many studies have been devoted to the identification of functionally important surface structures in murine, rat and human T lymphocytes. As a result of these studies, which have been greatly facilitated by the use of cloned T cell populations and monoclonal antibodies (MAbs), it has been proposed that several surface protein molecules that are clearly distinct from antigen receptors participate in antigen-dependent interactions between T lymphocytes and antigen-bearing cells, and/or may be involved in T cell activation.
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Cerottini, JC., MacDonald, H.R., Lowenthal, J., Shimonkevitz, R. (1985). Non Antigen-Specific Surface Molecules Involved in T Lymphocyte Function. In: Feldmann, M., Mitchison, N.A. (eds) Immune Regulation. Experimental Biology and Medicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4996-2_3
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DOI: https://doi.org/10.1007/978-1-4612-4996-2_3
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