Haemopoietic Cell Growth Factor: Characterisation and Mode of Action
The process of haemopoiesis provides a heterogenous population of peripheral blood cells with diverse morphological characteristics and functions. The site of production of these cells is mainly the bone marrow in the adult animal. In the marrow resides a population of pluripotent stem cells which give rise to the mature blood cells (see l). These stem cells can either self-renew (that is, form exact copies of themselves) or differentiate depending on the needs of the organism, in this way the stem cell population can be maintained throughout a life-time (and in fact could be maintained throughout several lifetimes2). A stem cell can also give rise to a series of progenitor cells upon division that are the precursor cells of the different lineages or blood cell types found in the circulation (see 3). The progeny of a p1uripotential stem cell are committed to a defined differentiation pathway whereby there is a restriction as to which mature blood cell type they will be able to yield4.
KeywordsLactate Radium Respiration Polypeptide Pyruvate
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