Abstract
The dose—response relation of many agonists yield sigmoidal (S-shaped) curves when the response is plotted against the logarithm of the dose (see Figure 8.1). There is no generally accepted theory that explains the shape of such curves; yet, we find that such curves are often approximately linear between 20% and 80% of the maximum response. In particular, many isolated tissue preparations display this linear segment. The data in the 20%–80% region may therefore be subjected to linear regression as given in Procedure 3, in which y = effect, or percent effect, and x = log dose. The regression line so determined might be used in the comparison of potency (Procedure 10) or in the analysis of the action of a competitive antagonist (Procedure 15). In each of these applications the regression lines are made parallel, and equieffective doses are determined.
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© 1987 Springer-Verlag New York Inc.
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Tallarida, R.J., Murray, R.B. (1987). Graded dose—response. In: Manual of Pharmacologic Calculations. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4974-0_9
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DOI: https://doi.org/10.1007/978-1-4612-4974-0_9
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-9380-4
Online ISBN: 978-1-4612-4974-0
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