Abstract
The use of the probit conversion for drawing smooth quantal log dose—effect curves was discussed in Procedure 9. Since there are no values of the probit corresponding to 0 and 100% effects the method of Procedure 9 does not handle such complete log dose—effect curves. The problem of analyzing such complete curves was addressed by Litchfield and Wilcoxon who gave a method for “correcting” the 0 and 100% effects. Although their method preceded the widespread use of calculators and computers, it is still widely used for determining ED50 and its 95% confidence limits.
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© 1987 Springer-Verlag New York Inc.
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Tallarida, R.J., Murray, R.B. (1987). Litchfield and Wilcoxon I: Confidence Limits of ED50. In: Manual of Pharmacologic Calculations. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4974-0_47
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DOI: https://doi.org/10.1007/978-1-4612-4974-0_47
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-9380-4
Online ISBN: 978-1-4612-4974-0
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