Dissociation Constant III: Perturbation Methods (Rate Constants in the Drug-Receptor Reaction)

  • Ronald J. Tallarida
  • Rodney B. Murray

Abstract

Consider a drug-receptor reaction
$$ D + R\mathop \rightleftharpoons \limits_{{k_2}}^{{k_1}} DR \to \cdots \to E, $$
where DR is the drug-receptor complex and E the effect at equilibrium. It may be possible to determine the forward and reverse rate constants k1 and k2 by the method of chemical relaxation. In this method the system is subjected to a small but sharp variation in some physical parameter upon which the value K(=k2/k1)depends. The restoration to equilibrium after this perturbation follows first-order kinetics, that is,
$$ \Delta E = \Delta {E_{\max }}{e^{ - t/\tau }}. $$
(14.1)

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Rodney B. Murray
    • 2
  1. 1.Department of PharmacologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Department of PharmacologyBiosearch Inc.PhiladelphiaUSA

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