Advertisement

Human T Cell Lymphotropic Viruses and Their Family of Diseases

  • L. Ratner
  • Robert C. Gallo

Abstract

Three classes of exogenous human retroviruses have been isolated, and designated human T-cell lymphotropic virus (HTLV) types I, II, and III. HTLV-I and -II are immortalizing and weakly cytopathic viruses, whereas HTLV-III is a nonimmortalizing, strongly cytopathic virus. HTLV-I is etiologically related to adult T-cell leukemia/lymphoma (ATLL). HTLV-III is the cause of the acquired immunodeficiency syndrome (AIDS). HTLV-II has been isolated on three occasions, from patients with a T cell variant of hairy cell leukemia, an intravenous drug abuser, and a hemophiliac. Because of the rarity of its detection, no clear disease association has been established for HTLV-II.

Keywords

Long Terminal Repeat Acquire Immunodeficiency Syndrome Bovine Leukemia Virus Hairy Cell Leukemia Long Terminal Repeat Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Robert-Guroff M, Sarngadharan NG, Gallo RC (1982) T-cell growth factor. In Growth and Maturation Factors. Wiley & Sons, New York, pp 267–309Google Scholar
  2. 1.
    Robert-Guroff M, Sarngadharan NG, Gallo RC (1982) T-cell growth factor. In Growth and Maturation Factors. Wiley & Sons, New York, pp 267–309Google Scholar
  3. 3.
    Gallo RC (1984) Human T-cell leukemia-lymphoma virus and T cell malignancies in adults. Cancer Surveys 3: 113–159Google Scholar
  4. 4.
    Wong-Staal F, Gallo RC (1985) The family of human T-lymphotropic leukemia viruses: HTLV-I as the cause of adult T-cell leukemia and HTLV-III as the cause of acquired immunodeficiency syndrome. Blood 65: 253–267PubMedGoogle Scholar
  5. 5.
    Wong-Staal F, Gallo RC (1985) Human T-lymphotropic retroviruses (HTLV). Nature 317: 395–403PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • L. Ratner
  • Robert C. Gallo

There are no affiliations available

Personalised recommendations