Abstract
Interferons constitute a group of closely related cellular proteins that exhibit potent antiviral activity. There is abundant experimental data indicating that the production of interferons in the course of viral infections is an integral part of the host response, and interferon treatment of animals and humans is associated with prophylactic and therapeutic antiviral effects. Although interferon was originally considered to inhibit viral multiplication within the cell without affecting host cell metabolism or function, it is now widely accepted that interferons can also affect cell division and function both in cell culture and in the animal [1]. If this is so, we might expect to find instances in which too much interferon, instead of being beneficial, might even prove inimical to the host. I will summarize here the results of experiments which show that interferon can induce disease in mice and rats, and then try to discuss the relevance of these findings to our understanding of the pathogenesis of some viral diseases.
Keywords
- Systemic Lupus Erythematosus
- Acquire Immune Deficiency Syndrome
- Glomerular Basement Membrane
- Newborn Mouse
- Mouse Hepatitis Virus
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Gresser, I. (1986). Interferon-induced Disease. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4958-0_27
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DOI: https://doi.org/10.1007/978-1-4612-4958-0_27
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