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Mapping Neutralization Domains of Viruses

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Book cover Concepts in Viral Pathogenesis II

Abstract

Animal viruses enter the host cell by attachment to a virus-specific host cell receptor followed by a chain of events that allows the particle to pass through the plasma membrane. This pathway may involve either the direct fusion of the viral envelope with the cytoplasmic membrane (paramyxoviruses) or internalization via endocytotic vesicles, called endosomes (togaviruses, myxoviruses, possibly also the picornaviruses). Available evidence suggests that the virion contained in the endosomes undergoes acid-induced structural rearrangements that lead to penetration (see ref. 1 for a review).

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Authors
  1. Eckard Wimmer
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  2. Emilio A. Emini
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  3. David C. Diamond
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Editor information

Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, Bethesda, Maryland, 20892, USA

    Abner Louis Notkins M.D.

  2. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1986 Springer Science+Business Media New York

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Wimmer, E., Emini, E.A., Diamond, D.C. (1986). Mapping Neutralization Domains of Viruses. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4958-0_19

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  • DOI: https://doi.org/10.1007/978-1-4612-4958-0_19

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