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Diabetes and Protein Glycosylation pp 43–65Cite as

Clinical Use

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Abstract

There is no question that periodic monitoring of glycosylated hemoglobin is useful for documenting the degree of glucose control that has prevailed during an interval of several weeks before the sample is taken, since the glycohemoglobin concentration reflects the time-averaged concentration of glucose within the erythrocyte during that period. Evidence supporting the correlation between glycohemoglobin levels and traditional methods of assessing glucose control in insulin-dependent diabetic patients is abundant.1–5 Correlations are best when multiple glucose measurements over several weeks are analyzed, and are not found when a single blood glucose or 24-hour urine glucose determination is used. A study of 18 counselors with insulin-de- pendent diabetes attending an 8-week camp session found that the percent sugar-free urine test was the best predictor of normal or elevated Hb A1c values, although there was also a significant correlation between Hb A1c and mean preprandial blood glucose concentrations.6 Two earlier studies had also found that Hb A1c correlated highly with glycosuria measured three times per day with Clinitest detection during the preceding 8 weeks.

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  1. Division of Endocrinology and Metabolism, University of Medicine and Denstistry of New Jersey, 07103, Newark, New Jersey, USA

    Margo Panush Cohen (Professor of Medicine and Chair)

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Cohen, M.P. (1986). Clinical Use. In: Diabetes and Protein Glycosylation. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4938-2_4

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