Skip to main content
SpringerLink
Log in

Review of the Effects of Anti-T-Cell Monoclonal Antibodies on Major and Minor GvHR in the Mouse

  • Conference paper
Experimental Hematology Today—1985

Part of the book series: Experimental Hematology Today ((HEMATOLOGY,volume 1985))

  • 30 Accesses

Abstract

Human bone marrow transplantation, as presently applied, almost exclusively utilizes cells taken from donors matched to the recipient at the major histocompatibility complex (MHC). The prime reason for this is to avoid or minimize the complications of graft-versus-host (GvH) reaction that would otherwise prove fatal to the marrow recipient. This recognition stems from the early work on GvH response across MHC barriers that was carried out in mouse, dog, and primate models by a number of notable investigators (1–6). These studies not only made apparent the importance of MHC matching to minimize or avoid GvHR, but provided much insight into the basic mechanisms of the reactions, including the identification of T-cells as the prime mediator for GvHR (7).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barnes, DWH, Ilbery PLT, Loutit JF (1958) Avoidance of secondary disease in radiation chimeras. Nature 181: 488

    Article  PubMed  CAS  Google Scholar 

  2. van Bekkum DW, Vos O, Weyzen WWH (1959) The pathogenesis of the secon- 17, dary disease after foreign bone marrow transplantation in X-irradiated mice. J Natl Cancer Inst 23: 75–89

    PubMed  Google Scholar 

  3. de Vries MJ, Crouche BG, van Putten LM, van Bekkum DW C 1 96 1) Pathogenic 18, changes in irradiated monkeys treated with bone marrow. J Natl Cancer Inst 27: 67–97

    Google Scholar 

  4. Cole LJ, Garver RM, OKunewick JP (1959) Lethal graft-versus-host reaction induced in X-irradiated F Hybrids by parental strain leukocytes. Transplant Bull 6: 429–432

    Article  PubMed  CAS  Google Scholar 

  5. Mathe G, Amiel JL, Schwarzenberg L, Mery AM (1 9 6 3) A method of reducing the incidence of the secondary syndrome in allogeneic marrow transplantation. Blood 22: 44–52

    Google Scholar 

  6. Thomas ED (1967) Observations on supralethal whole-body irradiationand marrow transplantation in man and dog. Ann NY Acad Sci 114: 393–396

    Article  Google Scholar 

  7. van Bekkum DW (1974) The double barrier in bone marrow transplantation. 21. Sem Hemat 1 1:325–339

    Google Scholar 

  8. van Bekkum DW, Wagemaker G, Vriesendorp HM (1979) Mechanisms and avoidance of graft-versus-host disease. Transplant Proc 11: 189-195 22.

    Google Scholar 

  9. Graff RJ, Snell GD (1969) Histocompatibility genes of mice. IX. The distribution of the alleles of the non- H-2 histocompatibility loci. Trans-plantation 8: 861–876 23.

    Google Scholar 

  10. Klein J (1973) List of congenic lines of mice. I. Lines with differences at alloantigen loci. Transplantation 15: 137–153

    Article  PubMed  CAS  Google Scholar 

  11. Klein J, Park JM (1973) Graft-versus- host reactions across different regions of the H-2 complex of the 24. mouse. J Exp Med 137: 1213–1225

    Article  PubMed  CAS  Google Scholar 

  12. Hamilton BL, Bevan MJ, Parkman R (1981) Anti-recipient cytotoxic T- lymphocyte precursors are present in the spleens of mice with acute graft versus host diseases due to minor histocompatibility antigens. J Immunol 126: 621–625

    PubMed  CAS  Google Scholar 

  13. Hamilton BL, Parkman R (1982) Kinetics of the anti-recipient cytotoxic cell response of mice with minor histocompatibility antigen graft-vs- host disease. J Immunol 128: 376–379

    PubMed  CAS  Google Scholar 

  14. Hamilton BL (1984) Absence of correlation between cytolytic T lymphocytes and lethal murine graft-versus- host disease in response to minor histocompatibility antigens. Trans-plantation 38: 357–360

    CAS  Google Scholar 

  15. Korngold R, Sprent J (1978) Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. J Exp Med 148: 1687–1698

    Article  PubMed  CAS  Google Scholar 

  16. Korngold R, Sprent J (1980) Negative selection of T-cells causing lethal graft-versus-host disease across minor histocompatibility barriers. Role of the H-2 complex. J Exp Med 151: 1114–1124

    Article  PubMed  CAS  Google Scholar 

  17. Korngold R, Sprent J (1982) Features of T-cells causing H-2 restricted lethal graft-vs-host disease across minor histocompatibility barriers. J Exp Med 155: 872–883

    Article  PubMed  CAS  Google Scholar 

  18. Korngold R, Sprent J (1983) Lethal GvHD across minor histocompatibility barriers: Nature of the effector cells and role of the H-2 complex. Immunological Rev 71: 5–28

    Article  CAS  Google Scholar 

  19. Rodt H, Ko 1 b HJ, Netzel B, Hoffman- Feger G, Scholz S, Haas RJ, Bender- Gotge C, Wundisch FF, Rieder I, Wilms K, The i rf e1 der S (1 9 8 0) Prevention and treatment of GvHD by anti-thymo- cyte globulin. In: Gale RG and Fox CF (eds) Biology of Bone Marrow Transplantation, New York, Academic Press, p. 22 1

    Google Scholar 

  20. Cobbold S, Martin G, Waldmann H (1985) Monoclonal antibodies can be used to control both GvHD and rejection in mouse models of bone marrow transplantation. Exp Hematol 13: 384

    Google Scholar 

  21. Thierfelder S, Hoffmann-Feger G, Rodt H, Cobbold SP, Waldman H (1 984) Influence of isotype on suppression of G v H with anti-Thy-1. Exp Hematol 12: 373

    Google Scholar 

  22. OKunewick JP, Meredith RF, Raikow RB, Buffo MJ, Jones DL (1982) Possibility of three distinct and separable components to fatal graft-vs-host reaction. Exp Hematol 10: 275–289

    Google Scholar 

  23. OKunewick JP, Meredith RF, Braunschweiger PG, Beschorner WE prevention of with the use Buffo MJ, Jones DL, (1982) Definition and graft-vs-host disease of monoclonal anti-bodies. Exp Hematol 10, Suppl 12:12– 22

    Google Scholar 

  24. OKunewick JP, Meredith RF, Braunschweiger PG, Beschorner WE prevention of with the use Buffo MJ, Jones DL, (1982) Definition and graft-vs-host disease of monoclonal anti-bodies. Exp Hematol 10, Suppl 12:12– 22

    Google Scholar 

  25. OKunewick JP, Cobbold SP, Thierfelder S (1984) Monoclonal antibody suppression of graft-vs-host reaction without the need for complement or ricin. Exp Hematol 12: 373

    Google Scholar 

  26. OKunewick JP, Buffo MJ, Kociban DL (1985) Possible independent roles for L y t - 1 + and Lyt-2+ T-cells in mouse minor histocompatibility ( MiHL) GvH reaction. Exp Hematol 13: 429

    Google Scholar 

  27. Meredith RF, OKunewick JP (19 8 3) Possibility of graft-vs-leukemia de-terminants independent of the major histocompatibility complex in allogeneic marrow transplantation. Transplantation 35: 378 – 385

    Google Scholar 

  28. Graff RJ (1970) Polymorphism of histocompatibility genes in the mouse. Transplant Proc 2: 15–23

    PubMed  CAS  Google Scholar 

  29. Warren RP, Storb R, Nguyen DD, Thomas ED (1977) The failure to demonstrate an involvement of human leukocyte group 5 antigens in graft-versus-host disease and marrow graft rejection. Transplantation 24: 89–91

    Article  PubMed  CAS  Google Scholar 

  30. Marshak-Rothstein A, Fink P, Gridley T, Raulet DH, Bevan MJ, Gefter ML (1979) Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus. J Immunol 122: 2491–2497

    PubMed  CAS  Google Scholar 

  31. Vallera DA, Soderling CCB, Carlson GJ, Kersey JH (19 8 1) Bone marrow transplantation across major histo-compatibility barriers in mice. Transplantation 31: 218–222

    Google Scholar 

  32. OKunewick JP, Beschorner WE, Buffo MJ, Kociban DL (1985) Histopathology of a possible graft-versus-host reaction induced by nude mouse spleen cells. Transplantation 39: 447–449

    Article  PubMed  CAS  Google Scholar 

  33. OKunewick JP, Meredith RF, Brozovich BJ, Seeman PR, Magliere K (1 9 8 0) Exponential relationship between spleen cell concentration and fatal GvH response following transplantation of allogeneic spleen/marrow mixtures. Transplantation 29: 507–510

    Google Scholar 

  34. Blacklock HA, Prentice HB, Gilmore M, Price-Jones E, Shey S, Tidman N, Ma D, Goldstein G, Janossy G, Hoffbrand AV (1983) Attempts at T-cell depletion using 0KT3 and rabbit complement to prevent acute graft versus host disease in allogeneic bone marrow transplantation. Exp Hematol 11, suppl 13: 37–40

    Google Scholar 

  35. Waldmann H, Hale G, Cobbold S, Clark M, Tighe H, Bindon C (1985) Rat monoclonal antibodies for bone marrow- transplantation (BMT): The CAMPATH series. Exp Hematol 13: 431

    Google Scholar 

  36. Cantor H, Boyce EA (1975) Functional subclasses of T lymphocytes bearing different Ly antigens. J Exp Med 141: 1376–1389

    Article  PubMed  CAS  Google Scholar 

  37. Ledbetter JA, Rouse RV, Miklem HS, Herzenberg LA (1980) T-cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. J Exp Med 152: 280–292

    Article  PubMed  CAS  Google Scholar 

  38. Huber B, Cantor H, Shen FW, Boyce EA (1976) Independent differentiative pathways of Ly-1 and Ly-2,3 subclasses of T-cells. J Exp Med 144:1128– 1133

    Google Scholar 

  39. Roehm NW, Alter BJ, Bach FH (1981) Lyt phenotypes of alloreactive pre-cursor and effector cytotoxic T lymphocytes. J Immunol 126: 353–358

    PubMed  CAS  Google Scholar 

  40. Vallera D, Soderling CCB, Kersey JH (1982) Bone marrow transplantation across major histocompatibility bar-riers in mice. III. Treatment of donor grafts with monoclonal antibodies directed against Lyt determi¬nants. J Immunol 128: 871–875

    Google Scholar 

  41. van Elven EH, Rolink AG, van der Veen F, Gleichmann E (1 98 1) Capacity of genetically different T-1 ymphocytes to induce lethal graft-versus-host response correlates with their capacity to generate suppression but not with their capacity to generate anti- F- killer cells. J Exp Med 153:1474– 1488

    Google Scholar 

  42. Vitale B, Jaksic B, Matosic M, Silobrcic V, Tomazic V (1976) Acute graft-vs-host reaction in mice. I. Cellular events. Transplantation 21: 502–510

    Google Scholar 

  43. Yuhas JM, Storer JB (1 9 6 9) On mouse strain differences in radiation re¬sistance: Hematopoietic death and the endogenous colony forming unit. Radiat Res 39: 608–622

    Google Scholar 

  44. Matzinger P, Zamoyska R (1982) A beginner’s guide to major histocompatibility complex function. Nature 297: 628

    Article  PubMed  CAS  Google Scholar 

  45. Cudkowicz G, Bennett M (1971) Peculiar immunobio1ogy of bone marrow allografts. II. Rejection of parental grafts by resistant F hybrid mice. J Exp Med 134: 1513–1528

    Google Scholar 

  46. Cudkowicz G, Lotzova E (1 973) Hemo-poietic cell-defined components of the major histocompatibility complex of mice: Identification of responsive and unresponsive recipients for bone marrow transplants. Transplant Proc 5: 1399–1405

    Google Scholar 

  47. Sprent J, Lefkovits I (1976) Effect of recent antigen priming on adaptive immune responses. IV Antigen induced selective recruitment of recirculating lymphocytes to the spleen demonstrable with a microculture system. J Exp Med 143: 1289–1298

    Google Scholar 

  48. Korngold R, Sprent J (1980) Selection of cytotoxic T-cell precursors specific for minor histocompatibility determinants. I. Negative selection across H-2 barriers induced with disrupted cells but not with gluter- aldehyde-treated cells: Evidence for antigen processing. J Exp Med 151: 314–327

    Google Scholar 

  49. van Bekkum DW, de Vries MJ (1967) Radiation Chimeras, New York, Academic Press

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research Laboratories, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, 15212, USA

    Dr. James P. OKunewick

Authors
  1. Dr. James P. OKunewick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Physiology Department, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA

    S. J. Baum

  2. Laboratory of Microbiology and Immunology, National Institute of Dental Research, NIH, 29782, Bethesda, MD, USA

    Dov H. Pluznik

  3. Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    L. A. Rozenszajn

  4. Department of Medical Laboratories, Meir Hospital, Kfar-Sava, Israel

    L. A. Rozenszajn

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag New York Inc.

About this paper

Cite this paper

OKunewick, J.P. (1986). Review of the Effects of Anti-T-Cell Monoclonal Antibodies on Major and Minor GvHR in the Mouse. In: Baum, S.J., Pluznik, D.H., Rozenszajn, L.A. (eds) Experimental Hematology Today—1985. Experimental Hematology Today, vol 1985. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4920-7_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4920-7_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96273-3

  • Online ISBN: 978-1-4612-4920-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation