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Immunoglobulin and T-Cell Receptor Gene Rearrangements in Human Acute Leukemias

  • Anand Raghavachar
  • C. R. Bartram
  • Bernhard Kubanek
Conference paper
Part of the Experimental Hematology Today book series (HEMATOLOGY, volume 1985)

Abstract

Development of immunological methods has made it possible to examine the cellular origin of leukemia cells in relation to their normal counterparts and acute lymphoblastic leukemia (ALL) is generally classified into the following major subgroups: T-ALL, B-ALL and common ALL (cALL) (1). Not infrequently, however, it is impossible to classify acute leukemias as B or T cell or nonlymphoid in origin despite examining lineage associated surface markers, as some malignancies represent stages of differentiation prior to the expression of lineage restricted surface markers. These limitations can now be overcome by utilizing the DNA rearrangement of immunoglobulin (Ig) and T cell receptor genes to reveal the clonality, cellular lineage, and stage of differentiation of such acute undifferentiated leukemias (AUL) (2).

Keywords

Acute Lymphoblastic Leukemia Gene Rearrangement Cell Acute Lymphoblastic Leukemia Myelomonocytic Cell Immunoglobulin Gene Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Anand Raghavachar
    • 1
  • C. R. Bartram
    • 1
  • Bernhard Kubanek
    • 1
  1. 1.DRK-Blutspendezentrale Ulm und Abteilung für Transfusionsmedizin der Universität UlmUlm/DonauFederal Republic of Germany

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