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Glycosphingolipids as Specific Differentiation-Markers and Differentiation-Inducers for Human Myelogenous Leukemia Cells: A Monosialyl Glycosphingolipid, Ganglioside GM3, is Highly Potent for Induction of Monocytic Differentiation of Human Myeloid and Monocytoid Cell Lines, HL-60 and U937 Cells

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Experimental Hematology Today—1985

Part of the book series: Experimental Hematology Today ((HEMATOLOGY,volume 1985))

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Abstract

Multiple surface-marker analysis recently developed in terms of immunologic, cytogenetic and enzymatic characteristics showed that human acute myelogeous leukemias and their established cell lines were blocked in cell maturation at certain, recognizable differentiation-steps such as myeloblast or promyelocyte stage. Many research-groups including us have demonstrated that some of them could be induced to differentiate into mature functioning cells by various chemical agents, implying the possibility that some leukemic cells are capable of maturation under certain environmental circumstances. This phenomenon gives profound therapeutic importance as well as one of the basic experimental models, providing a clue for elucidating the fundamental mechanisms of regulation for growth and differentiation of hematopoietic cells.

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Author information

Authors and Affiliations

  1. Division of Hemopoiesis, Institute of Hematology, 3311-1 Yakushiji, Minami-kawachi-machi, Kawachi-gun, Tochigi-ken, 329-04, Japan

    Masaki Saito, Hisao Nojiri & Yasusada Miura

  2. Division of Hematology, Department of Medicine, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi-machi, Kawachi-gun, Tochigi-ken, 329-04, Japan

    Masaki Saito, Hisao Nojiri & Yasusada Miura

Authors
  1. Masaki Saito
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  2. Hisao Nojiri
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  3. Yasusada Miura
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Editor information

Editors and Affiliations

  1. Physiology Department, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA

    S. J. Baum

  2. Laboratory of Microbiology and Immunology, National Institute of Dental Research, NIH, 29782, Bethesda, MD, USA

    Dov H. Pluznik

  3. Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    L. A. Rozenszajn

  4. Department of Medical Laboratories, Meir Hospital, Kfar-Sava, Israel

    L. A. Rozenszajn

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© 1986 Springer-Verlag New York Inc.

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Saito, M., Nojiri, H., Miura, Y. (1986). Glycosphingolipids as Specific Differentiation-Markers and Differentiation-Inducers for Human Myelogenous Leukemia Cells: A Monosialyl Glycosphingolipid, Ganglioside GM3, is Highly Potent for Induction of Monocytic Differentiation of Human Myeloid and Monocytoid Cell Lines, HL-60 and U937 Cells. In: Baum, S.J., Pluznik, D.H., Rozenszajn, L.A. (eds) Experimental Hematology Today—1985. Experimental Hematology Today, vol 1985. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4920-7_11

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  • DOI: https://doi.org/10.1007/978-1-4612-4920-7_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96273-3

  • Online ISBN: 978-1-4612-4920-7

  • eBook Packages: Springer Book Archive

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