Primates pp 711-723 | Cite as

Virus-Associated Neoplastic and Immunosuppressive Diseases of Nonhuman Primates

  • Harvey Rabin
  • Raoul E. Benveniste
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Several primate colonies have experienced outbreaks of neoplastic disease accompanying immunosuppressive syndromes. These outbreaks possess the characteristics of an infectious disease, and in several cases viruses have been isolated and shown to have disease-inducing potential. The colonies involved have been at the California, New England, Oregon, and Washington Regional Primate Research Centers in the United States, and at the Institute of Experimental Pathology and Therapy in the U.S.S.R.

Keywords

Lymphoma Oncol Diarrhea Neutropenia Hunt 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benveniste RE, Todaro GJ (1977) Evolution of primate oncornaviruses: an endogenous virus from langurs (Presbytis spp.) with related virogene sequences in other Old World monkeys. Proc Natl Acad Sci USA 74: 4557–4561.PubMedCrossRefGoogle Scholar
  2. Benveniste RE, Stromberg K, Morton WR, Tsai C-C, Giddens WE Jr (In press) Association of retroperitoneal fibromatosis with type D retroviruses. In: Salzman L (ed) Animal models of retrovirus infection. Academic, New York.Google Scholar
  3. Daniel MD, King NW, Letvin NL, Hunt RD, Sehgal PK, Desrosiers RC (1984) A new type D retrovirus isolated from macaques with an immunodeficiency syndrome. Science 223: 602–605.PubMedCrossRefGoogle Scholar
  4. Daniel MD, Letvin NL, King NW, Kannigi M, Sehgal PK, Hunt RD, Kanki PJ, Essex M, Desrosiers RC (1985) Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228: 1201–1204.PubMedCrossRefGoogle Scholar
  5. Deinhardt F, Falk L, Wolfe L, Schudel A, Nonoyama M, Lai P, Lapin B, Yakovleva L (1978) Susceptibility of marmosets to Epstein-Barr virus-like baboon herpesviruses. Prim Med 10: 163–170.Google Scholar
  6. Desrosiers RC, Daniel MD, Butler CV, Schmidt DK, Letvin NL, Hunt RD, King NW, Barker CS, Hunter E (1985) Retrovirus-D/New England and its relation to Mason-Pfizer monkey virus. J Virol 54: 552–560.PubMedGoogle Scholar
  7. Dyachenko A, Kokosha L, Lapin B, Yakovleva L, Agrba V (1981) Detection of baboon herpesvirus DNA in the tissues of hemoblastosis diseased and healthy monkeys from Sukhumi nursery USSR. J Sov Oncol 2: 48–51.Google Scholar
  8. Falk L, Deinhardt F, Nonoyama M, Wolfe LG, Bergholz C, Lapin B, Yakovleva L, Agrba V, Henle G, Henle W (1976) Properties of a baboon lymphotropic herpesvirus related to Epstein-Barr virus. Int J Cancer 18: 798–807.PubMedCrossRefGoogle Scholar
  9. Gardner MB, Marx PA (1985) Simian acquired immunodeficiency syndrome. Adv Viral Oncol 5: 57–81.Google Scholar
  10. Giddens WE Jr, Morton WR, Hefti E, Panem S, Ochs H (1983) Enzootic retroperitoneal fibromastosis in Macaca spp. In: Kalter SS (ed) Viral and immunological diseases in nonhuman primates. Alan R Liss, New York, pp 249–253.Google Scholar
  11. Giddens WE Jr, Tsai C-C, Morton WR, Ochs HD, Knitter GH, Blakely GA (1985) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: pathologic observations and transmission studies. Amer J Pathol 119: 253–263.Google Scholar
  12. Gravell M, London WT, Houff SA, Madden DL, Dalakas MC, Sever JL, Osborn KG, Maul DH, Henrickson RV, Marx PA, Lerche NW, Prahalada S, Gardner MB (1984) Transmission of simian acquired immunodeficiency syndrome (SAIDS) with blood or filtered plasma. Science 223: 74–76.PubMedCrossRefGoogle Scholar
  13. Heberling R, Bieber C, Kalter S (1982) Establishment of a lymphoblastoid cell line from a lymphomatous cynomolgous monkey. In: Yohn D, Blakeslee J (eds) Adv in Compar Leuk Res. Elsevier/North Holland, New York, pp 385–386.Google Scholar
  14. Hefti E, Ip J, Giddens WE Jr, Panem S (1983) Isolation of a unique retrovirus, MNV-1, from Macaca nemestrina. Virology 127: 309–319.PubMedCrossRefGoogle Scholar
  15. Henderson LE, Sowder R, Smythers G, Benveniste RE, Oroszlan S (1985) Purification and N-terminal amino acid sequence comparison of structural proteins from retrovirus-D/Washington and Mason-Pfizer monkey virus. J Virol 55: 778–787.PubMedGoogle Scholar
  16. Henrickson RV, Maul DH, Osborn KG, Gardner MB (1983) Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposi-like skin lesions. Lancet 2: 869–873.PubMedGoogle Scholar
  17. Henrickson RV, Maul DH, Lerche NW, Osburn KG, Lowenstine LJ, Prahalada S, Sever JL, Madden DL, Gardner MB (1984a) Clinical features of simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. Lab Anim Sci 34: 140–145.PubMedGoogle Scholar
  18. Henrickson RV, Arthur LO, Gilden RV, Sever JL, Levy SA, Munn RJ, Gardner MB (1984) Simian AIDS: isolation of a type D retrovirus and transmission of the disease. Science 223: 1083–1086.PubMedCrossRefGoogle Scholar
  19. Holmberg CA, Osburn BI, Terrell TG, Manning JS (1978) Cellular immunologic studies of malignant lymphoma in rhesus macaques. Amer J Vet Res 39: 469–472.PubMedGoogle Scholar
  20. Homma T, Kanki PJ, King NW Jr, Hunt RD, O’Connell MJ, Letvin NL, Daniel MD, Desrosiers RC, Yang CS, Essex M (1984) Lymphoma in macaques: association with virus of human T lymphotrophic family. Science 225: 716–718.PubMedCrossRefGoogle Scholar
  21. Hunt RD, Blake BJ, Chalifoux LV, Sehgal PK, King NW, Letvin NL (1983) Transmission of naturally occurring lymphoma in macaque monkeys. Proc Natl Acad Sci USA 80: 5085–5089.PubMedCrossRefGoogle Scholar
  22. Kanki PJ, McLane MF, King NW Jr, Letvin NL, Hunt RD, Sehgal PK, Daniel MD, Desrosiers RC, Essex M (1985) Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III. Science 228: 1199–1201.PubMedCrossRefGoogle Scholar
  23. Kanki PJ, Kurth P, Becker W, Dreesman G, McLane MF, Essex M (1985b) Antibodies to simian T-lymphotropic retrovirus type III in African green monkeys and recognition of STLV-III viral proteins by AIDS and related sera. Lancet 1: 1330–1332.PubMedCrossRefGoogle Scholar
  24. King NW, Hunt RD, Letvin NL (1983) Histopathologic changes in macaques with an acquired immunodeficiency syndrome (AIDS). Amer J Pathol 113: 382–388.Google Scholar
  25. Komuro A, Watanabe T, Miyoshi I, Hayami M, Tsujimoto H, Seiki M, Yoshida M (1984) Detection and characterization of simian retroviruses homologous to human T-cell leukemia virus type 1. Virology 138: 373–378.PubMedCrossRefGoogle Scholar
  26. Lapin BA (1976) Epidemiology of leukemia among baboons of Sukhumi monkey colony. In: Clemmesen J, Yohn DS (eds) Comp Leuk Res (1975), Bibl Haemat No 43. S Karger, Basel, pp 212–215.Google Scholar
  27. 722.
    Letvin NL, Eaton KA, Aldrich WR, Sehgal PK, Blake BJ, Schlossman SF, King NW, Hunt RD (1983a) Acquired immunodeficiency syndrome in a colony of macaque monkeys. Proc Natl Acad Sci USA 80: 2718–2722.PubMedCrossRefGoogle Scholar
  28. Letvin NL, King NW, Daniel MD, Aldrich WR, Blake BJ, Hunt RD (1983b) Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue. Lancet 2: 599–602.PubMedCrossRefGoogle Scholar
  29. Letvin NL, Daniel MD, Seghai PK, Chalifoux LV, King NW, Hunt RD, Aldrich WR, Holley K, Schmidt DK, Desrosiers RC (1984) Experimental infection of rhesus monkeys with type D retrovirus. J Virol 52: 683–686.PubMedGoogle Scholar
  30. London WT, Madden DL, Gravell M, Dalakas MC, Houff SA, Sever JL, Henrickson RV, Maul DH, Osborn KG, Gardner MB (1983) Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposi-like skin lesions. Lancet 2: 869–873.PubMedCrossRefGoogle Scholar
  31. Manning JS, Griesemer RA (1974) Spontaneous lymphoma of the nonhuman primate. Lab Anim Sci 24 (1): 204–210.PubMedGoogle Scholar
  32. Manning JS, Griesemer RA (1978) Viruses detected in cells explanted into tissue culture from naturally occurring malignant lymphoma in rhesus monkeys. Curr Microbiol 1: 157–162.CrossRefGoogle Scholar
  33. Marx PA, Bryant ML, Osborn KG, Maul DH, Lerche NW, Lowenstine LJ, Kluge JD, Zaiss CP, Henrickson RV, Shiigi SM, Wilson BJ, Malley A, Olson LC, Arthur LO, Gilden RV, Barker CS, Hunter E, Munn RJ, Heidecker G, Gardner MB (1985) Isolation of a new strain of SAIDS type D retrovirus from Celebes black macaques (Macaca nigra) with immunodeficiency and retroperitoneal fibromatosis. J Virol 56: 571–578.PubMedGoogle Scholar
  34. Marx PA, Maul DH, Osborn KG, Lerche NW, Moody P, Lowenstein LJ, Henrickson RV, Arthur LO, Gravell M, London WT, Sever JL, Levy JA, Munn RJ, Gardner MB (1984) Simian AIDS: Isolation of a type D retrovirus and disease transmission. Science 223: 1083–1086.PubMedCrossRefGoogle Scholar
  35. Miyoshi I, Yoshimoto S, Fujishita M, Tagachi H, Kubonishi I, Niiya K, Minezawa M (1982) Natural adult T-cell leukemia virus infection in Japanese monkeys. Lancet 2: 658.PubMedCrossRefGoogle Scholar
  36. Neubauer RH, Rabin H, Strnad BC, Lapin BA, Yakovleva LA, Indzie E (1979) Antibody responses to Herpesvirus papio antigens in baboons with lymphoma. Int J Cancer 23: 186–192.PubMedCrossRefGoogle Scholar
  37. Rabin H (1985) In vitro studies of Epstein-Barr virus and other lymphotropic herpesviruses of primates. In: Roizman B, Lopez C (eds) The herpesviruses, vol 4. Plenum, New York/London, pp 147–170.Google Scholar
  38. Rangan SRS, Martin LW, Gormus BJ, Wang N (1985) Characterization of rhesus monkey (M. mulatto) lymphoid cellculture containing herpesvirus particles. Proc ASM p s-32.Google Scholar
  39. Rasheed S, Rongey RW, Nelson-Rees WA, Rabin H, Neubauer RH, Bruszeski J, Esra G, Gardner MB (1977) Establishment of a cell line with associated Epstein-Barr-like virus from a leukemic orangutan. Science 198: 407–409.PubMedCrossRefGoogle Scholar
  40. Saxinger WC, Lange-Wantzin G, Thomsen K, Lapin B, Yakovleva L, Li Y-W, Guo H-G, Robert-Guroff M, Blattner WA, Ito Y, Gallo RC (1984) Human T-cell leukemia virus: a diverse family of related exogenous retroviruses of humans and old world primates. Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Laboratory, New York, pp 323–330.Google Scholar
  41. Shaw GM, Harper ME, Hahn BH, Epstein LG, Gajdusek DC, Price RW, Navia BA, Petito CK, O’Hara CJ, Groopman JE, Cho E-S, Oleske JM, Wong-Staal F, Gallo RC (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science 227: 177–181.PubMedCrossRefGoogle Scholar
  42. Shiigi SM, Wilson BJ, Malley A, Howard CF Jr, McNulty WP, Olson J (In press) Virus-associated deficiencies in the mitogen reactivity in Celebes black macaques (Macaca nigra). J Clin Immunopath.Google Scholar
  43. Stowell RE, Smith EK, Espana C, Nelson VG (1971) Outbreak of malignant lymphoma in rhesus monkeys. Lab Invest 35: 476–479.Google Scholar
  44. Stromberg K, Benveniste RE, Arthur LO, Rabin H, Giddens WE Jr, Ochs H, Morton WR, Tsai C-C (1984) Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis. Science 224: 289–292.PubMedCrossRefGoogle Scholar
  45. Tsai C-C, Giddens WE Jr, Morton WR, Rosenkranz SL, Ochs HD, Benveniste RE (1985a) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: epidemiologic studies. Lab Anim Sci 35: 460–464.PubMedGoogle Scholar
  46. Tsai C-C, Giddens WE Jr, Ochs HD, Morton WR, Knitter GH, Blakley GA, Benveniste RE (In press b) Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques: clinical and immunologic studies. Lab Anim Sci.Google Scholar
  47. Yamamoto N, Hinuma Y, zur Hausen H, Schneider J, Hunsmann G (1983) African green monkeys are infected with adult T-cell leukemia virus or a closely related agent. Lancet 1: 240.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Harvey Rabin
  • Raoul E. Benveniste

There are no affiliations available

Personalised recommendations