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The Main Intrinsic Polypeptide and Intercellular Communication in the Ocular Lens

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Development of Order in the Visual System

Part of the book series: Cell and Developmental Biology of the Eye ((EYE))

Abstract

We discuss here, the role of the Main Intrinsic Polypeptide (MIP) of the ocular lens fiber cell membrane, and its putative role in intercellular communication in the lens. In order to best understand the evidence which has been used in the consideration of MIP function, brief and non-comprehensive reviews of both the gap junction and lens biology are provided.

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References

  • Asada, Y., and M. Bennett. 1971. Experimental alterations of coupling resistance at an electrotonic synapse. J. Cell Biol. 49: 159–172

    Article  PubMed  CAS  Google Scholar 

  • Baker, T., D. Caspar. C. Hollinshead and D. Goodenough. 1983. Gap junction structures. IV asymmetric features revealed by low-dose electron microscopy. J. Cell Biol. 96: 204–216

    Article  PubMed  CAS  Google Scholar 

  • Barr, L., M. Dewey and W. Berger. 1965. Propagation of action potentials and the structure of the nexus in cardiac muscle. J. Gen. Physiol. 48: 797–823

    Article  PubMed  CAS  Google Scholar 

  • Beebe, D., and D. Feagans. 1981. A tissue culture system for studying lens cell differentiation. Vision Res. 21: 113–118

    Article  PubMed  CAS  Google Scholar 

  • Benedetti, E., I. Dunia, C. Bentzel, A. Vermorken, M. Kibbelaar and H. Bloemendal. 1976. A portrait of plasma membrane specializations in eye lens epithelium and fibers. Biochim. et Biophys. Acta 457: 353–384

    CAS  Google Scholar 

  • Benedetti, E., I. Dunia and H. Bloemendal. 1974. Proc. Natl. Acad. Sci. 71: 5073–5077

    Article  PubMed  CAS  Google Scholar 

  • Benedetti, E., and P. Emmelot. 1968. Hexagonal array of subunits in tight junctions separated from isolated rat liver plasma membranes. J. Cell Biol. 38: 15–24

    Article  PubMed  CAS  Google Scholar 

  • Bennedetti, E., and P. Emmelot. 1965. Electron microscope observations on negatively stained plasma membranes isolated from rat liver. J. Cell Biol. 26: 299

    Article  Google Scholar 

  • Bennett, M., and D. Goodenough. 1978. Neurosciences Res. Program Bull. 16: 443

    Google Scholar 

  • Bennett, M., E. Aljure, Y. Nakajima, and G. Pappas. 1963 Electrotonic junctions between teleost spinal neurons: Electrophysiology and Ultrastructure. Science 141: 262–264

    Article  PubMed  CAS  Google Scholar 

  • Bloemendal, H. 1977. The vertebrate eye lens. Science 197: 127–138

    Article  PubMed  CAS  Google Scholar 

  • Bloemendal, H. 1979. Lens proteins as markers of terminal differentiation. Ophthalmic Res. 11: 243–253

    Article  CAS  Google Scholar 

  • Bloemendal, H., A. Zweers, F. Vermorken, I. Dunia and E. Benedetti. 1972. The plasma membranes of eye lens fiber. Biochemical and structural characterization. Cell Differentiation 1: 91–106

    Article  PubMed  CAS  Google Scholar 

  • Bok, D., J. Dockstader and J. Horwitz. 1982. Immunocytochemical localization of the lens main intrinsic polypeptide (MIP26) in communicating junctions. J. Cell Biol. 92: 213–220

    Article  PubMed  CAS  Google Scholar 

  • Bonting, L., L. Caravaggio and N. Hawkins. 1963. Studies on sodium potasium activated ATPase. Its role in cation transport in the lens of cat, calf, and rabbit. Arch. Biochem. Biophys. 101: 47– 55

    Google Scholar 

  • Broekhuyse, R., E. Kuhlman and H. Winkens. 1979. Lens membranes VII. MIP is an immunologically specific component of lens fiber cell membranes and is identical with 26kd band protein. Exp. Eye Res. 29: 303–313

    Article  PubMed  CAS  Google Scholar 

  • Caspar, D., D. Goodenough, L. Makowski and W. Phillips. 1977. Gap junction structure I. Correlated electron microscopy and X-ray diffraction. J. Cell Biol. 74: 605–628

    Article  PubMed  CAS  Google Scholar 

  • Chalcroft, J. and S. Bullivant. 1970. An interpretation of liver cell membrane and junction structure based on observation of freeze fracture replicas of both sides of the fracture. J. Cell Biol. 47: 49

    Article  PubMed  CAS  Google Scholar 

  • Cohen, A. 1965. The electron microscopy of the normal human lens. Invest. Ophthal. Vis. Sci. 4: 433–446

    CAS  Google Scholar 

  • Counis, M., E. Chaudun, Y. Courtois, J. Carreau, J. Jack and R. Clayton. 1982. Differential protein synthesis of chick embryonic lenses during in vitro differentiation. Exp. Eye Res. 34: 861–876

    Article  PubMed  CAS  Google Scholar 

  • Dewey, M. and L. Barr. 1962. Intercellular connections between smooth muscle cells: The Nexus. Science 137: 670

    Article  PubMed  CAS  Google Scholar 

  • Dewey, M. and L. Barr. 1964. A study of the structure and distribution of the nexus. J. Cell Biol. 23: 553–585

    Article  PubMed  CAS  Google Scholar 

  • Duncan, G. 1969. The site of ion restricting membranes in the toad lens. Exp. Eye Res. 8: 406–412

    Article  PubMed  CAS  Google Scholar 

  • Dunia, I., C. Ghosh, E. Benedetti, A. Zweers and H. Bloemendal. 1974. FEBS Lett. 45: 139–144

    Article  PubMed  CAS  Google Scholar 

  • Epstein, M. and N. Gilula. 1977. A study of communication specificity between cells in culture. J. Cell Biol. 75: 769–787

    Article  PubMed  CAS  Google Scholar 

  • Evans, W. and J. Gurd. 1972. Preparation and properties of nexuses and lipid-enriched vesicles from mouse liver plasma membranes. Biochem. J. 128: 691–700

    PubMed  CAS  Google Scholar 

  • Finbow, M., S. Yancey, R. Johnson and J. Revel. 1980. Independent lines of evidence suggesting a major gap junction protein with a molecular weight of 26,000. Proc. Natl. Acad. Sci. 77: 970–974

    Article  PubMed  CAS  Google Scholar 

  • FitzGerald, P. and D. Goodenough. (in preparation) Development and characterization of differentiating rat lens cultures for MIP expression and communication competence.

    Google Scholar 

  • FitzGerald, P.G., D. Bok and J. Horwitz. 1983. Immnocytochemical localization of the main intrinsic polypeptide (MIP) in ultrathin frozen sections of rat lens. J. Cell Biol. 97: 1491–1499

    Article  PubMed  CAS  Google Scholar 

  • FitzGerald, P.G., V. Cirillo and D. Goodenough. 1984. Rat lens cell differentiation in culture: A useful model for the study of MIP and intercellular communication. Invest. Ophthal. Vis. Sci. 25: 154

    Google Scholar 

  • FitzGerald, P.G., D. Bok and J. Horwitz. 1984. Distribution of the main intrinsic polypeptide in lens fiber membrane domains. Proc. of the 42nd Ann. Mtg. of the Electron Microscope Society of America, pp. 122–124, San Fransisco Press, S.F., CA

    Google Scholar 

  • Flagg-Newton, J., I. Simpson and W. Lowenstein. 1979. Permeability of cell to cell membrane channels in mammalian cell junctions. Science 205: 404–407

    Article  PubMed  CAS  Google Scholar 

  • Friend, D. and N. Gilula. 1972. Variations in tight and gap junctions in mammalian tisues. J. Cell Biol. 53: 758–776

    Article  PubMed  CAS  Google Scholar 

  • Friedlander, M. 1980. Immunological approaches to the study of myogenesis and lens fiber junction formation. Current Topics in Developmental Biology 14: 321–358

    Article  PubMed  CAS  Google Scholar 

  • Gilula, N., O. Reeves and A. Steinbach. 1972. Metabolic coupling, ionic coupling, and cell contacts. Nature 235: 262–265

    Article  PubMed  CAS  Google Scholar 

  • Goodenough, D. and J. Revel. 1970. A fine structural analysis of intercellular junctions in the mouse liver. J. Cell Biol. 45: 272–290

    Article  PubMed  CAS  Google Scholar 

  • Goodenough, D. 1979. Lens gap junctions: A structural hypothesis for non-regulated low resistance intercellular pathways. Invest. Ophthal. Vis. Sci. 18: 1104–1122

    CAS  Google Scholar 

  • Goodenough, D. and W. Stoeckenius. 1972. The isolation of mouse hepatocyte gap junctions. J. Cell Biol. 54: 646–656

    Article  PubMed  CAS  Google Scholar 

  • Goodenough, D., J. Dick and J. Lyons. 1980. Lens metabolic cooperation: A study of mouse lens transport and permeability visualized with freeze substitution autoradiography and electron microscopy. J. Cell Biol. 86: 576–589

    Article  PubMed  CAS  Google Scholar 

  • Goodenough, D., D. Paul and K. Culbert. 1978. Correlative gap junction structure birth defects: Original article series, XIV: 83–97

    Google Scholar 

  • Gorin, M., S. Yancey, J. Cline, J. Revel and J. Horwitz. 1984. cDNA cloning of MIP26: A new tool for the study of lens structure and development. Invest. Ophthal. Vis. Sci. 25: 153

    Google Scholar 

  • Gros, D., B. Nicholson and J. Revel. 1983. Comparative analysis of the gap junction protein from rat heart and liver: Is there a tissue specificity of gap junction? Cell 35: 539–549

    Article  PubMed  CAS  Google Scholar 

  • Hanna, C. 1965. Changes in RNA, DNA, and protein synthesis in the developing lens. Invest. Ophthal. Vis. Sci. 4: 480–491

    CAS  Google Scholar 

  • Hanna, R.B., G.D. Pappas and M. Bennett. 1984. The fine structure of identified electrotonic synapses following increased coupling resistance. Cell Tissue Research 235: 243–249

    Article  PubMed  CAS  Google Scholar 

  • Harding, J. and K. Dilley. 1976. Structural proteins of the mammalian lens: A review with emphasis on changes in development, aging and cataract. Exp. Eye Res. 22: 1–73

    Article  PubMed  CAS  Google Scholar 

  • Henderson, D., H. Eibel and K. Weber. 1979. Structure and biochemistry of mouse hepatocyte gap junctions. J. Mol. Biol. 132: 193–218

    Article  PubMed  CAS  Google Scholar 

  • Hertzberg, E. and N. Gilula. 1979. Isolation and characterization of gap junctions from rat liver. J. Biol.

    Google Scholar 

  • Hertzberg, E. and N. Gilula. 1982. Liver gap junctions abd lens fiber juctions: Comparative analysis and calmodulin interaction. Cold Spring Harbor Symp. Quant. Biol. 46: 639–645

    Google Scholar 

  • Hertzberg, E., D. Anderson, M. Friedlander and N. Gilula. 1982. Comparative analysis of the major polypeptides from liver gap junctions and lens fiber junctions. J. Cell Biol. 92: 53–59

    Article  PubMed  CAS  Google Scholar 

  • Hertzberg, E. 1980. Biochemical and immunological approaches to the study of gap junctional communication. In Vitro 121: 1057–1067

    Article  Google Scholar 

  • Hyde, A., B. Blondel, A. Matter, J. Cheneval, B. Filloux and L. Girardier. 1969. Homo- and heterocellular junctions in cell cultures: An electrophysiological and morphological study. Prog. Brain Res. 31: 283–311

    Article  PubMed  CAS  Google Scholar 

  • Janssen-Timmen, U., R. Dermeitzel, U. Frixen, A. Leibstein. O. Traub and K. Willecke. 1983. Immunocytochemical localization of the gap junction 26k protein in mouse liver plasma membranes. EMBO Journal 2: 295–302

    PubMed  CAS  Google Scholar 

  • Kensler, R. and D. Goodenough. 1980. Isolation of mouse myocardial gap junctions. J. Cell Biol. 86: 755–764

    Article  PubMed  CAS  Google Scholar 

  • Kinsey, V. and D. Reddy. 1965. Studies on the crystalline lens Invest. Ophthal. Vis. Sci. 4: 104–116

    CAS  Google Scholar 

  • Kistler, J. and S. Bullivant. 1980. Lens gap junctions and orthagonal arrays are unrelated. FEBS Letters 111: 73–78

    Article  PubMed  CAS  Google Scholar 

  • Kuszak, J., J. Alcala and H. Maisel. 1981. Biochemical and structural features of chick lens gap junctions. Exp. Eye Res. 33: 157–166

    Article  PubMed  CAS  Google Scholar 

  • Kuszak, J., H. Maisel and C. Harding. 1978. Gap junctions of chick lens fiber cells. Exp. Eye Res. 27: 495–498

    Article  PubMed  CAS  Google Scholar 

  • Kuszak, J., J. Rae, B. Pauli and R. Weinstein. 1982. Rotary replication of the lens gap junction. J. Ultrastruct. Res. 81: 249–256

    Article  PubMed  CAS  Google Scholar 

  • Kuwabara, T. 1975. The maturation of the lens cell: A morphologic study. Exp. Eye Res. 20: 427–443

    Article  PubMed  CAS  Google Scholar 

  • Lasser, A. and E. Balzs. 1972. Biochemical and fine structure studies on the water insoluble components of the calf lens. Exp. Eye Res. 13: 292–308

    Article  PubMed  CAS  Google Scholar 

  • Leeson, T. 1971. Lens of the rat eye: An electron microscope and freeze-etch study. Exp. Eye Res. 11: 78–82

    Article  PubMed  CAS  Google Scholar 

  • Lo, C. and N. Gilula. 1979. Gap junctional communication in the post implantation mouse embryo. Cell 18: 411–422

    Article  PubMed  CAS  Google Scholar 

  • Lowenstein, W. 1979. Junctional intercellular communication and the control of growth. Biochim et Biophys Acta 560: 1–65

    Google Scholar 

  • Lowenstein, W. 1966. Permeability of membrane junctions. Annals, New York Academy of Science 441–472

    Google Scholar 

  • Lowenstein, W. and Y. Kanno. 1964. Studies on an epithelial gland cell junction. J. Cell Biol. 22: 565–586

    Article  Google Scholar 

  • McAvoy, J. 1980. Induction of the eye lens. Differentiation 17: 137–149

    Article  PubMed  CAS  Google Scholar 

  • Michalke, W. and W. Lowenstein. 1971. Communication between cells of different types. Nature 232: 121–122

    Article  PubMed  CAS  Google Scholar 

  • Miller, T. and D. Goodenough. 1985. gap junction structure after experimental alternations in junctional channel conductance. J. Cell Biol. (in press)

    Google Scholar 

  • Mousa, G. and J. Trevethick. 1977. Differentiation of T4 Rat Lens epithelial cells in tissue culture. Development Biology 60: 14–25

    Google Scholar 

  • Nicholson, B., L. Takemoto, M. Hunkapiller, L. Hood and J. Revel 1983. Differences between liver gap junction protein and the lens MIP 26 from rat: Implications for tissue specificity of gap junctions. Cell 32: 967–987

    Article  PubMed  CAS  Google Scholar 

  • Nikaido, H. and E. Rosenberg. 1984. Functional reconstitution of lens junction proteins into proteoliposomes. Proc. of 42nd Ann. Mtg. of the Electron Microscope Society of America, pp. 130–132

    Google Scholar 

  • Okada, T., G. Eguchi and M. Takeichi. 1973. The retention of differentiated properties by lens epithelial cells in clonal cell culture. Dev. Biol. 34: 321–333

    Article  PubMed  CAS  Google Scholar 

  • Paul, D. and D. Goodenough. 1983. Preparation, characterization and localization of an antisera against bovine MP26, an integral membrane protein from lens fiber cell plasma membranes. J. Cell Biol. 96: 625–631

    Article  PubMed  CAS  Google Scholar 

  • Payton, B., M. Bennett and G. Pappas. 1969. Permeability and structure of junctional membranes at an electrotonic synapse. Science 166: 1641

    Article  PubMed  CAS  Google Scholar 

  • Peracchia, C. and L. Peracchia 1980. Gap junction dynamics: reversible effects of hydrogen ions. J. Cell Biol. 87: 719–727

    Article  PubMed  CAS  Google Scholar 

  • Peracchia, C. 1977. Gap junctions: Structural changes after uncoupling procedures. J. Cell Biol. 72: 626–641

    Article  Google Scholar 

  • Peracchia, C. and L. Peracchia. 1980. Gap junction dynamics: Reversible effects of divalent cations. J. Cell Biol. 87: 708–718

    Article  PubMed  CAS  Google Scholar 

  • Peracchia, C. and S. Girsch. 1984. Calmodulin-mediated gating of lens gap junction channels in vesicles. Proc. of 42nd Ann. Mtg. of the Electron Microscope Society of America, pp 134–137

    Google Scholar 

  • Peracchia, C. 1978. Calcium effects on gap junction structure and cell coupling. Nature 271: 669–671

    Article  PubMed  CAS  Google Scholar 

  • Phillipson, B., L. Hanninen and E. Balazs. 1975. Cell contacts in human and bovine lenses. Exp. Eye Res. 21: 205–219

    Article  Google Scholar 

  • Piatigorski, J., H. Webster and S. Craig. 1972. Protein synthesis and ultrastructure during the formation of embryonic chick lens fibers In Vitro. Develop. Biol. 27: 176–189

    Google Scholar 

  • Piatigorski, J. 1981. Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19: 134–153

    Article  Google Scholar 

  • Pitts, J. and J. Simms. 1977. Permeability of junctions between animal cells. Exp. Cell Res. 104: 153–163

    Article  PubMed  CAS  Google Scholar 

  • Rae, J. 1973. The potential difference of the frog lens. Exp Eye Res. 15: 485–494

    Article  PubMed  CAS  Google Scholar 

  • Rae, J. 1974. The movement of procion dyes in the crystalline lens Invest. Ophthal. Vis. Sci. 13: 147–150

    CAS  Google Scholar 

  • Rae, J. 1979. The electrophysiology of the crystalline lens. Current Topics in Eye Research 1: 37

    PubMed  CAS  Google Scholar 

  • Rae, J. and J. Kuszak. 1983. The electrical coupling of epithelium and fibers in the frog lens. Exp. Eye Res. 36: 317–326

    Article  PubMed  CAS  Google Scholar 

  • Rae, J., R. Thomson and R. Eisenberg. 1982. The effect of 2-4 dinitrophenol on cell-cell communication in the frog lens. Exp. Eye Res. 35: 597–609

    Article  PubMed  CAS  Google Scholar 

  • Rafferty, N. and E. Esson. 1974. An electron microscope study of adult mouse lens: Some ultrastructural specializations. J. Ultrastructural Res. 46: 239–253

    Article  CAS  Google Scholar 

  • Raviola, E., D. Goodenough and G. Raviola. 1980. Structure of rapidly frozen gap junctions. J. Cell Biol. 87: 273–279

    Article  PubMed  CAS  Google Scholar 

  • Revel, J. and M. Karnovsky. 1967. Hexagonal arrays of subunits in intercellular junctions of the mouse heart and liver. J. Cell Biol. 33: 7–12

    Article  Google Scholar 

  • Rose, B. and W. Lowenstein. 1975. Permeability of cell junctions depends on local cytoplasmic calcium activity. Nature 254: 250–252

    Article  PubMed  CAS  Google Scholar 

  • Rose, B. and R. Rick. 1978. Intracellular pH, intracellular free Ca, and junctional cell-cell coupling. J. Membrane Biology 44: 377–415

    Article  CAS  Google Scholar 

  • Rose, B., I. Simpson and W. Lowenstein. 1977. Calcium ions produce graded changes in permeability of membrane channels in cell junctions. Nature 267: 625–628

    Article  PubMed  CAS  Google Scholar 

  • Russel, P., W. Robison and J. Kinoshita. 1981. A new method for the rapid isolation of the intrinsic membrane proteins from the lens. Exp. Eye Res. 32: 511–516

    Article  Google Scholar 

  • Schuetze, S. and D. Goodenough. 1982. Dye transfer between cells of the embryonic chick lens becomes less sensitive to C02 treatment with development. J. Cell Biol. 92: 694–705

    Article  PubMed  CAS  Google Scholar 

  • Schwarzzmann, G., H. Wiegandt, B. Rose, A. Zimmerman, D. Ben-Haim and W. Lowenstein. 1981. Diameter of cell-cell junctional channels as probed with neutral molecules. Science 213: 551–554

    Article  Google Scholar 

  • Simpson, I., B. Rose and W. Lowenstein. 1977. Size limit of molecules permeating the junctional membrane channels. Science 195: 294–296

    Article  PubMed  CAS  Google Scholar 

  • Smelser. G. 1965. Embryology and morphology of the lens. Invest. Ophthal. Vis. Sci. 4: 398–410

    CAS  Google Scholar 

  • Spray, D., A. Harris and M. Bennet. 1981. Gap Junctional conductance is a simple and sensitive function of intracellular pH. Science 211: 712–715

    Article  PubMed  CAS  Google Scholar 

  • Subak-Sharpe, H., R. Burk and J. Pitts. 1969. Metabolic cooperation between biochemically marked mammalian cells in tissue. J. Cell Sci. 4: 353–367

    PubMed  CAS  Google Scholar 

  • Takemoto, L. and J. Hansen. 1981. Gap junctions from the lens: Purification and characterization by chemical cross-linking reagent. Biochem. Biophys. Res. Commun. 99: 324–331

    Article  PubMed  CAS  Google Scholar 

  • Takemoto, L., J. Hansen and J. Horwitz. 1981. Interspecies conservation of the MIP of the lens membrane. Comp. Biochem. Physiol. 68B: 101–106

    CAS  Google Scholar 

  • Traub, 0. and K. Willecke. 1982. Cross reaction of antibodies against liver gap junction protein with lens fiber junction protein with lens fiber junction protein (MIP) suggests structural homology between these tissue specific gene products. Biochem. Biophys. Res. Commun. 109: 895–901

    Article  PubMed  CAS  Google Scholar 

  • Tsunematsu, Y., H. Fukui and J. Kinoshita. 1978. Studies on primary cultures of adult lens cells from normal and hereditary cataractous mice. Exp. Eye Res. 26: 671–685

    Article  PubMed  CAS  Google Scholar 

  • Turin, L. and A. Warner. 1980. Intracellular pH in early xenopus embryos: Iits effect on current flow between blastomeres. J. Physiol 300: 489–504

    PubMed  CAS  Google Scholar 

  • Turner, L. and A. Warner. 1977. Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo. Nature 270: 56–57

    Article  Google Scholar 

  • Unakar, N. and J. Tsui. 1980. Sodium potassium dependent ATPase I. cytochemical localization in normal and cataractous lenses Invest. Ophthal. Vis. Sci. 19: 630

    CAS  Google Scholar 

  • Unwin, P. and G. Zampighi. 1980. Structure of the junctions between communicating cells. Nature 283: 545–549

    Article  PubMed  CAS  Google Scholar 

  • Waggoner, P. and H. Maisel. 1978. Immunofluorescent study of a chick lens fiber cell membrane polypeptide. Exp. Eye Res. 27: 151–157

    Article  PubMed  CAS  Google Scholar 

  • Wanko, T. and M. Gavin. 1959. Mmicroscope study of the lens fibers. J. Biophys. and Biochem. Cytol. 6: 97–102

    Article  CAS  Google Scholar 

  • Warner, A. and P. Lawrence. 1982. Permeability of gap junctions at the segmental border in insect epidermis. Cell 28: 243–252

    Article  PubMed  CAS  Google Scholar 

  • Weir, M. and C. Lo. 1982. Gap junctional communication compartments in the drosophila wing disk. Proc. Natl. Acad. Sci. 79: 3232–3235

    Article  PubMed  CAS  Google Scholar 

  • Young, R.R. and H.W. Fulhorst. 1966. Regional differences in protein synthesis within the lens of the rat. Invest. Ophthal. Vis. Sci. 5: 288–297

    CAS  Google Scholar 

  • Zampighi, G., S. Simon, J. Robertson, T. Mcintosh and M. Costello. 1982. On the structural organization of the isolated bovine lens fiber junction. J. Cell Biol. 93: 175–189

    Article  PubMed  CAS  Google Scholar 

  • Zampighi, G. and J. Robertson. 1973. Fine structure of the synaptic discs separated from the goldfish medulla oblongata. J. Cell Biol. 56: 92–105

    Article  PubMed  CAS  Google Scholar 

  • Zampighi, G. and P. Unwin. 1979. Two forms of isolated gap junctions. J. Mol. Biol. 135: 451–464

    Article  PubMed  CAS  Google Scholar 

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  1. Paul G. FitzGerald
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  1. Department of Biology, Temple University, Philadelphia, Pennsylvania, 19122, USA

    S. Robert Hilfer  & Joel B. Sheffield  & 

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FitzGerald, P.G. (1986). The Main Intrinsic Polypeptide and Intercellular Communication in the Ocular Lens. In: Hilfer, S.R., Sheffield, J.B. (eds) Development of Order in the Visual System. Cell and Developmental Biology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4914-6_4

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  • DOI: https://doi.org/10.1007/978-1-4612-4914-6_4

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