Studies on the Structure and Function of Ribosomal RNA
Our understanding of the structure and function of ribosomal RNA has evolved rapidly during the past few years. Complete primary structures for 16S, 23S, and 5S rRNA (and their analogs) from a wide range of organisms and organelles are now available, as are accurate secondary structure models that are helping us to understand the higher order folding of these molecules (reviewed in Woese et al., 1983; Brimacombe et al., 1983; Ebel et al., 1983; Noller, 1984). Current efforts in this area are focused on understanding tertiary and quaternary structure of rRNA and the nature of its involvement in protein synthesis.
KeywordsCodon Aspergillus Adenine Pyrimidine Erythromycin
Unable to display preview. Download preview PDF.
- Ebel, J.P., Branlant, C., Carbon, P., Ehresmann, B., Ehresmann, C., Krol, A., Stiegler, P. (1983). In Structure, Dynamics, Interactions and Evolution of Biological Macromolecules, ed. Helene, C. D. Reidel, Boston, pp. 177–193.Google Scholar
- Fox, G.F., Woese, C.R. (1975). 5S RNA secondary structure. Nature 256: 505–507.Google Scholar
- Grosjean, H.J., de Henau, S., Crothers, D.M. (1978). On the physical basis for ambiguity in genetic coding interactions. Proc. Nat. Acad. Sci. USA 75: 610–614.Google Scholar
- Gutell, R.R., Weiser, B., Woese, C.R., Noller, H.F. (1985). Comparative anatomy of 16S-like ribosomal RNA. Prog. Nucl. Acid Res. Mol. Biol 32: 156–216.Google Scholar
- Moazed, D., Van Stolk, B., Douthwaite, S., Noller, H.F. (1986b). (submitted for publication). Noller, H.F. (1974). Topography of 16S RNA in 30S ribosomal subunits. Nucleotide sequences and location of sites of reaction with kethoxal. Biochem 13: 4694–4703.Google Scholar
- Noller, H.F. (1979) Structure and topography of ribosomal RNA. In Ribosomes, eds. Chambliss, G., et al., University Park Press, Baltimore, pp. 3–22.Google Scholar
- Rich, A. (1974) How transfer RNA may move inside the ribosome. In Ribosomes, eds. Nomura, A., Tissieres, A., Lengyel, P. Cold Spring Harbor, New York, pp. 871–884.Google Scholar
- Seilhammer, J., Olsen, G.J., Cummings, D.J. (1984). Paramecium mitochondrial genes. I. Small subunit rRNA sequence and microevolution. J. Biol. Chem 259: 5167–5172.Google Scholar
- Sor, F., Fukuhara, H. (1980). Nucleotide sequence of the genes for the mitochondrial 15S ribosomal RNA of yeast. C.R. Acad. Sci. Paris 291: 933–936.Google Scholar
- Woese, C.R. (1979). Just-so stories and Rube Goldberg machines: speculations on the origin of the protein synthetic machinery. In Ribosomes, eds. Chambliss, G., et al., University Park Press, Baltimore, pp. 357–373.Google Scholar