Abstract
Accuracy is particularly crucial to an organism during protein biosynthesis, and the mRNA-directed polymerization of amino acids proceeds with a remarkably low frequency of error, as noted elsewhere in this volume. At the ribosome, the selection of the amino acid is mediated by base-pairing between an mRNA codon and an aminoacyl-tRNA (aa-tRNA) anticodon. However, this interaction is insufficient to account for the accuracy of protein biosynthesis (Grosjean et al., 1978), and the molecular mechanism by which the translational machinery magnifies its discrimination between correct and incorrect codon-anticodon pairs is not yet understood.
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Johnson, A.E., Janiak, F., Dell, V.A., Abrahamson, J.K. (1986). The Aminoacyl-tRNA·Elongation Factor Tu·GTP Ternary Complex and Its Role in Aminoacyl-tRNA Selection at the Ribosome. In: Hardesty, B., Kramer, G. (eds) Structure, Function, and Genetics of Ribosomes. Springer Series in Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4884-2_31
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DOI: https://doi.org/10.1007/978-1-4612-4884-2_31
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