Abstract
Until the mid-1960s, our knowledge of adverse drug effects in the clinical setting derived from two primary sources: 1) the known pharmacology of the drugs used, and 2) informal observations leading to anecdotal case histories reported to journals, government agencies, and other interested parties. For example, it was recognized that as a concomitant of their primary pharmacologic effect, anticoagulants were responsible for bleeding in some patients; that CNS-depressant drugs sometimes produced excessive respiratory depression, drowsiness, and even coma on occasion; and that insulin sometimes caused hypoglycemia. This knowledge was primarily qualitative because data providing the frequency of the clinical toxicity of the many drugs used in clinical practice were not available. Unanticipated serious toxicity of drugs was discovered after substantial clinical usage as anecdotal case reports accumulated.
Keywords
- Oral Contraceptive
- Adverse Drug Reaction
- Adverse Drug Effect
- Bone Marrow Depression
- Venous Thromboembolic Disease
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Jick, H. (1986). Adverse Drug Reactions. In: Maronde, R.F. (eds) Topics in Clinical Pharmacology and Therapeutics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4864-4_21
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DOI: https://doi.org/10.1007/978-1-4612-4864-4_21
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