Functional Studies with Monoclonal Antibodies Against Function-Associated Leukocyte Antigens
Lymphocyte function-associated antigen-1 (LFA-1) has initially been described in the mouse system (1,2). Monoclonal antibodies (mAbs) specific for the human counterpart to murine LFA-1 have subsequently been produced in several laboratories (3–6). Anti-LFA-1 mAbs inhibit a variety of T cell functions including cytotoxic T cell (CTL) activity (1–6), natural killer (NK) cell activity (3–6), killer (K) cell activity (6), T cell-dependent immunoglobulin (Ig) synthesis (1), and lectin-induced T cell proliferation (1,2,5). The inhibiting effect of anti-LFA-1 mAbs was shown to be caused by a blockade of cell—cell contact, required for cytotoxic activity (effector—target) or T cell activation (T—macrophage interaction) (2,7).
KeywordsNatural Killer Natural Killer Cell Activity Cell Mediate Immune Function Lymphocyte Function Associate Antigen Polymorphic Determinant
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