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Functional Studies with Monoclonal Antibodies Against Function-Associated Leukocyte Antigens

  • Frank Miedema
  • Fokke G. Terpstra
  • Cornelius J. M. Melief

Abstract

Lymphocyte function-associated antigen-1 (LFA-1) has initially been described in the mouse system (1,2). Monoclonal antibodies (mAbs) specific for the human counterpart to murine LFA-1 have subsequently been produced in several laboratories (3–6). Anti-LFA-1 mAbs inhibit a variety of T cell functions including cytotoxic T cell (CTL) activity (1–6), natural killer (NK) cell activity (3–6), killer (K) cell activity (6), T cell-dependent immunoglobulin (Ig) synthesis (1), and lectin-induced T cell proliferation (1,2,5). The inhibiting effect of anti-LFA-1 mAbs was shown to be caused by a blockade of cell—cell contact, required for cytotoxic activity (effector—target) or T cell activation (T—macrophage interaction) (2,7).

Keywords

Natural Killer Natural Killer Cell Activity Cell Mediate Immune Function Lymphocyte Function Associate Antigen Polymorphic Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Frank Miedema
  • Fokke G. Terpstra
  • Cornelius J. M. Melief

There are no affiliations available

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