Expression of Lymphocyte Antigens on Blast Cells from Patients with Chronic Granulocytic Leukemia
Chronic granulocytic leukemia (CGL) is a myeloproliferative disorder and is associated, in more than 90% of cases, with a karyotypic marker, the Philadelphia chromosome (Ph1) (1,2). Although during the chronic phase of the disease the blood picture is dominated by leukemic granulocytes of various maturation stages, the disease is not confined to the granulocyte lineage. Isoenzyme (G6PD) studies have revealed that in most patients non-lymphoid cells in the peripheral blood are in majority derived from the malignant clone (3,4). Such studies have also shown involvement of B lymphoid cells in CGL (5), and together with additional evidence this has led to the notion that the target cell for malignant transformation in CGL is a common progenitor for myeloid cells and B lymphocytes (6). Based on cell membrane marker studies during CGL blast crisis, the involvement of T cell progenitors in CGL is controversial (6–8,12). Clonal evolution of CGL cells in the blast crisis of the disease (2) and/or the inability of CGL cells to mature to well-defined T cells (6,12) may be at the basis of this controversy.
KeywordsProliferative Response Blast Cell Giant Cell Tumor Giant Cell Tumor Blast Crisis
Unable to display preview. Download preview PDF.
- 6.Greaves, M.F. 1982. “Target” cells, differentiation and clonal evolution in chronic granulocytic leukaemia: a “model” for understanding the biology of malignancy. In: Chronic granulocytic leukaemia, M.T. Shaw, ed. Praeger Publishers, New York, pp. 15–47.Google Scholar
- 9.Lansdorp, P.M., F.O. Oosterhof, and W.P. Zeijlemaker. 1985. Colony-forming cells in chronic granulocytic leukemia. I. Proliferative responses to growth factors. Leuk. Res. In press.Google Scholar
- 10.Lansdorp, P.M., J.G.J. Bauman, M.J.E. Bos, A.E.G. Kr. von dem Borne, F.O. Oosterhof, P.V. Mourik, P.A.T. Tetteroo, and W. P. Zeijlemaker. 1985. Colony-forming cells in chronic granulocytic leukemia. II. Analysis of membrane markers. Leuk. Res. In press.Google Scholar