Expression of Antigens Present on Hematopoietic Progenitor Cells by Cells of Certain Hematopoietic Lineages

  • Masatoshi Takaishi
  • Shu Man Fu
Conference paper


Utilizing non-lymphoid cell lines as immunogens, a series of monoclonal antibodies have been established and shown to have selective reactivities to non-lymphoid cells. Two of them (K 15.1.9 and H 8.4.5) have been studied more extensively. They have been found to exhibit differing reactivities to CFU-GM and BFU-E progenitor cells as well as to more mature hematopoietic cells. This report describes our investigation with these two antibodies.


Bone Marrow Cell Hematopoietic Progenitor Cell Myeloid Origin Large Cell Population Human Erythroleukemia Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yen, S.H., F. Gaskin, and S.M. Fu. 1983. Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermedi¬ate filaments of the vimentin class. Am. J. Pathol. 113: 373.PubMedGoogle Scholar
  2. 2.
    Chiorazzi, N., S.M. Fu, and H.G. Kunkel. 1980. Stimulation of human B lymphocytes by antibodies to IgM and IgG: Functional evidence for the expression of IgG on B-lymphocyte surface membranes. Clin. Immunol. Immunopathol 15: 301.PubMedCrossRefGoogle Scholar
  3. 3.
    Gottlieb, A.B., S.M. Fu, D.T.Y. Yu, C.Y. Wang, J.P. Halper, and H.G. Kunkel. 1979. The nature of the stimulatory cell in human allogeneic and autologous MLC reactions: role of isolated IgM-bearing B cells. J. Immunol. 123: 1497.PubMedGoogle Scholar
  4. 4.
    Messner, H.A., H. Jamal, and C. Izaguirre. 1982. The growth of large megakaryocyte colonies from human bone marrow. J. Cell. Physiol. Suppl. 1: 45.PubMedCrossRefGoogle Scholar
  5. 5.
    Wang, C.Y., S.M. Fu, and H.G. Kunkel. 1979. Isolation and immunological characterization of a major surface glycoprotein (gp54) preferentially expressed on certain human B cells. J. Exp. Med. 149: 1424.PubMedCrossRefGoogle Scholar
  6. 6.
    Pessano, S., L. Bottero, J. Faust, M. Trucco, A. Palumbo, L. Pegoraro, B. Lange, C. Brezim, J. Borst, C. Terhorst and G. Rovera. 1983. Differentiation antigens of human hemopoietic cell: Patterns of reactivity of two monoclonal antibodies. Cancer Res. 43: 4812.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Masatoshi Takaishi
  • Shu Man Fu

There are no affiliations available

Personalised recommendations