Abstract
The occurrence of Schwann cells in the central nervous system (CNS) of humans has been recognized for many years. These Schwann cells and peripheral-type myelin have been reported by some to represent regenerative processes (Klintworth 1964, Druckman 1955) to be associated with destructive lesions within the CNS (Payan and Levine 1965, Hughes and Brownell 1963, Bernstein et al. 1973) and to occur in the absence of any known lesion (DeMyer 1965, Adelman and Aronson 1972, Sung et al. 1981). Compression of the spinal cord owing to abnormalities of the vertebral column such as intervertebral disc protrusion (Druckman and Mair 1953, Mair and Druckman 1953) or to tumor (Druckman and Mair 1953) is also associated with intraspinal Schwann cells. Finally, axons myelinated by Schwann cells are often present in plaques in multiple sclerosis (Feigin and Popoff 1966, Feigin and Ogata 1971, Ghatak et al. 1973, Itoyama et al. 1983, Ogata and Feigin, 1975). The papers cited here are more selective than exhaustive in order to point out that in the human being the presence of Schwann cells within the CNS is a rather nonspecific response, as suggested by Koeppen and colleagues (1968), and may represent a reactin to both mechanical and metabolic injury (Adelman and Aronson 1972).
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Gilmore, S.A., Sims, T.J. (1986). The Role of Schwann Cells in the Repair of Glial Cell Deficits in the Spinal Cord. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4846-0_9
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DOI: https://doi.org/10.1007/978-1-4612-4846-0_9
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