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Drug Discovery and Development pp 151–176Cite as

Biochemical Approaches for Evaluating Drug—Receptor Interactions

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Abstract

A productive drug screening program entails various levels of analysis. Although it is ultimately necessary to demonstrate a bioogical response in intact animals, in vivo tests are labor-intensive and require significant quantities of compound, limiting their utility as primary screens. More desirable are simple, inexpensive tests that allow for the rapid identification of inactive or less active compounds. This can be achieved in many instances by measuring an in vitro biochemical response related to the action of a particular drug class. Such tests require only small amounts of sample and can be used for analyzing dozens of compounds in a matter of hours. By providing the pharmacologist and chemist with information about potency, efficacy, and structure-activity characteristics, this methodology enables them to select a few lead agents that can then be subjected to more detailed examination in secondary and tertiary screens.

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Authors
  1. S. J. Enna
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Editor information

Editors and Affiliations

  1. Drug Discovery Administration, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, New Jersey, USA

    Michael Williams

  2. Biomedical Research Department, Stuart Pharmaceuticals, ICI Americas Inc., Wilmington, Delaware, USA

    Jeffrey B. Malick

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© 1987 The Humana Press Inc.

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Enna, S.J. (1987). Biochemical Approaches for Evaluating Drug—Receptor Interactions. In: Williams, M., Malick, J.B. (eds) Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-4612-4828-6_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4828-6_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9180-0

  • Online ISBN: 978-1-4612-4828-6

  • eBook Packages: Springer Book Archive

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