Drug Delivery Systems

  • Joseph V. Bondi
  • D. G. Pope


The term “drug delivery” is truly a catch phase of the 1980s, few journals or periodicals having neglected to review the state of the art (Alper, 1984; Hildebrand, 1983; Banakar, 1984; Rogers, 1982; Check, 1984; Anderson and Kim, 1984; Zaffaroni, 1980; Inhorn, 1981; Banker and Rhodes, 1979; Senyie et al., 1985). However, although these newer concepts in drug delivery point toward a disappearance of traditional methods of drug therapy, it is likely that the bulk of pharmaceutical dosage forms, such as tablets, capsules, suspensions, and solutions for oral or parenteral use will enjoy continued wide use and acceptance. The science surrounding these dosage forms has progressed significantly in terms of the knowledge required to make better tablets, to understand the role of disintegrants, and to optimize inert ingredient ratios through sophisticated formulation design (Lachman et al., 1976; Lieberman and Lachman, 1980).


Drug Delivery Drug Release Dosage Form Drug Delivery System Control Release 
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  1. Alper, J. (1984) Drug Delivery, High Technol. 4 (10), 89 - 94Google Scholar
  2. Alving, C. R., Steck, E. A., Edgar, A., Chapman, W. L., Waits, V. B., Hendricks, L. D., Schwartz, G. M., and Hanson, W. L. (1978) Therapy for leishmaniasis superior efficacies of liposome- encapsulated drugs. Proc. Natl. Acad. Sci. USA 75, 2959–2963.PubMedCrossRefGoogle Scholar
  3. Anderson, J. M. and Kim, S. W., eds. (1984) Recent Advances in Drug Delivery Systems. Plenum, New York.Google Scholar
  4. Baker, J. A. F. and Stanford, G. D. (1979) Slow Release Devices as Aids in the Control of Ticks Infesting the Ears of Cattle in the Republic of South Africa, in Recent Advances in Acarology vol. II ( Rodiquez, J. D. ed.) Academic, N.Y.Google Scholar
  5. Baker, R. W. and Lonsdale, H. K. (1974) Controlled Release: Mechanisms and Rates, in Controlled Release of Biologically Active Agents ( Tanquary, A. C. and Lacey, R. E., eds.) Plenum, New York.Google Scholar
  6. Baker, R. W., Tuttle, M. E., and Helwing, R. (1984) Novel erodible polymer for the delivery of macromolecules. Pharm. Technol. February, 26–30.Google Scholar
  7. Banakar, U. V. (1984) Drug release mechanism of membrane-moderated drug delivery. Pharm. Manufact. September, 33–56.Google Scholar
  8. Bangham, A. D. Standish, M. M. and Watkins, J. C. (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Bio. 13, 238–252.CrossRefGoogle Scholar
  9. Banker, G. S. and Rhodes, C. T. (1979) Modern Pharmaceutics. Marcel Dek- ker, New York.Google Scholar
  10. Bechgaard, H. and Ladefoged, K. (1978) Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets. J. Pharm. Pharmacol. 30, 690–692.PubMedCrossRefGoogle Scholar
  11. Becker, B. A. and Hays, E. E. (1958) Prolongation and potentiation of oral codeine analgesia in the rat. Proc. Soc. Exp. Biol. Med. 99, 17–19.PubMedGoogle Scholar
  12. Bernstein. B. S.. Hyman, S., and Kapoor, R. C. (1981) US Patent 4, 284, 444.Google Scholar
  13. Blackshear, P. J., Dorman, F. D., Blackshear, P. L., Varco, R. L., and Buchwald, H. (1972) The design and initial testing of an implantable infusion pump. Surg. Gynecol. Obstet. 134, 51–55.PubMedGoogle Scholar
  14. Blackshear, P. J., Dorman, F. D„ Blackshear, P. L., Buckwald, H., and Varco, R. L. (1973) US Patent 3, 731, 681.Google Scholar
  15. Blythe, R. H. (1956) US Patent 2, 738, 303.Google Scholar
  16. Bodor, N. (1977) Novel Approaches for the Design of Membrane Transport Properties of Drugs, in Design of Biopharmaceutical Properties through Prodrugs and Analogs ( Roche, E. G., ed.) American Pharmaceutical Association, Washington, DC.Google Scholar
  17. Brooke, D. and Washkuhn, R. J. (1977) Zero-order drug delivery system; theory and preliminary testing. J. Pharm. Sci. 66, 159 - 162.PubMedCrossRefGoogle Scholar
  18. Brownlee, M. and Cerami, A. (1979) A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin. Science 206, 1190–1191.PubMedCrossRefGoogle Scholar
  19. Brudnev, N. (1959) Ion-exchange resin complexes in oral therapv. Can. Pharm. J. Sci. Sect. 92 (5), 245–258.Google Scholar
  20. Campbell, P. S. and Chandrasekaran, S. K. (1983) US Patent 4,379,454, April 12.Google Scholar
  21. Chabala, J. C., Mrozik, H., Torman, R. L., Eskola, P., Lusi, A., Peterson, L. H. Woods, M. F., Fisher, M. H., Campbell, W. C, Egerton, J. R., and Ostlind, D. A. (1980) Ivermectin: A new broad-spectrum antiparasitic agent. J. Med. Chem. 23, 1134–1136.PubMedCrossRefGoogle Scholar
  22. Check, W. A. (1984) New drugs and drug delivery systems in the year 2000. Am. Pharm. 24 (9), 44–56.Google Scholar
  23. Chien, Y. W. (1978) Method to Achieve a Sustained Drug Delivery—The Physical Approach: Implants, in Sustained and Controlled Release Drug Delivery Systems ( Robinson, J. R., ed.) Marcel Dekker, New York.Google Scholar
  24. Chien, Y. W. (1982) Ocular Controlled Release Drug Administration, in Novel Drug Delivery Systems ( Chien, Y. W., ed.) Marcel Dekker, New York.Google Scholar
  25. Colley, C. M. and Ryman, B. E. (1974) Model for lysosomal storage disease and a possible method of therapy. Biochim. Soc. Trans. 2 (5), 871–872.Google Scholar
  26. Colton, C. K. (1969) Permeability and transport studies in batch and flow dialyzers and application to hemodialysis. Doctoral dissertation, Massachusetts Institute of Technology.Google Scholar
  27. Dewey, D. W., Lee, H.J., and Marston, H. R. (1958) Provision of cobalt to ruminants by means of heavy pellets. Nature 18, 1367–1371.CrossRefGoogle Scholar
  28. Donaruma, L. G. and Vogl, O., eds. (1978) Polymeric Drugs. Academic, New York.Google Scholar
  29. Drake, C. F. and Brecklehurst, J. R. (1984) Glass encapsulated materials. US Patent 4,449, 981.Google Scholar
  30. Dresback, D. S. (1980a) Delivery system. US Patent 4,220, 152.Google Scholar
  31. Dresback, D. S. (1980b) Controlled release delivery system. US Patent 4,222, 153.Google Scholar
  32. Egerton, J. R.. Birnbaum,J., Blair, L. S., Chabala, J. C., Conroy, J., Fisher, M. H., Mrozik, H., Ostlind, D. A., Wilkins, C. A., and Campbell, W. C. (1980) 22,23-Dihydroavermectin Bl, A new broad spectrum antiparasitic agent. Br. Vet. J. 136, 89–97.Google Scholar
  33. Fisch, H., Angerhofer, R. A., and Nelson, J. H. (1977) Evaluation of a carbamate-impregnated flea and tick collar for dogs. J. Am. Vet. Med. Assoc. 171, 269–270.PubMedGoogle Scholar
  34. Flynn, G. L., Yalkowsky, S. H., and Roseman, T. J. (1974) Mass transport phenomena and models: Theoretical concepts. J. Pharm. Sci. 63, 479–510.PubMedCrossRefGoogle Scholar
  35. Folckemer, F. B., Hanson, R. E., and Miller, A. (1967) Resin compositions comprising organophosphorus pesticides. US Patent 3,852, 416.Google Scholar
  36. Folkman, J. and Long, D. M. (1964) The use of silicone rubber as a carrier for prolonged drug therapy. J. Surg. Res. 4, 139.PubMedCrossRefGoogle Scholar
  37. Freed, S. C. and Hays, E. E. (1959) Non-amphetamine anorectic agent. Am. J. Med. Sci. 238, 55–59.PubMedCrossRefGoogle Scholar
  38. Freedom of Information Summary (1984) Paratect cartridge for use in Cattle, NADA 134 - 779, Pfizer, New York.Google Scholar
  39. Good, W. R. (1978) Diffusion of Water Soluble Drugs From Initially Dry Hydrogels, in Polymeric Delivery Systems ( Kostelnik, R. J., ed.) Gordon and Breach Science, New York.Google Scholar
  40. Graham, N. B. and Wood, D. A. (1982) Hydrogels and biodegradable polymers for the controlled deliverv of drugs. Polymer News 8, 230–236.Google Scholar
  41. Grass, G. M. and Robinson, M. J. (1959) US Patent 2,875,130, February 24.Google Scholar
  42. Gregoriadis, G., ed. (1979a) Drug Carriers in Biology and Medicine. Academic, London.Google Scholar
  43. Gregoriadis, G. (1979b) Liposomes, in Drug Carriers in Biology and Medicine ( Gregoriadis, G., ed.) Academic, London.Google Scholar
  44. Gregoriadis, G., ed. (1984) Liposome Technology vol. I—III, CRC, Boca Raton, Florida.Google Scholar
  45. Grubb, L. M. and Baxter, J. K. (1974) Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide. US Patent 3,852, 416.Google Scholar
  46. Harrigan, R. M. (1977) Drug delivery device for preventing contact of undissolved drug with the stomach lining. US Patent 4,055, 178.Google Scholar
  47. Harris, F. W. (1984) Controlled Release From Polymers Containing Pendent Bioactive Sustituents, in Medical Applications of Controlled Release vol. I ( Langer, R. S. and Wise, D. L., eds.) CRC, Boca Raton, Florida.Google Scholar
  48. Heller, J. (1984a) Bioerodible Systems, in Medical Applications of Controlled Release (vol. I ( Langer, R. S. and Wise, D. L., eds.) CRC, Boca Raton, Florida.Google Scholar
  49. Heller, J. (1984b) Controlled Drug Release From Poly(orthoesters), in Proceedings11th International Symposium on Controlled Release Bioactive Materials (Meyers, W. E. and Dunn, R. L., eds.) Ft. Lauderdale, Florida, July 23–25.Google Scholar
  50. Hermelin, V. M. (1959) US Patent 2, 887, 438.Google Scholar
  51. Higuchi, T. (1961) Rate of release of medicaments from ointment bases containing drugs in suspension. J. Pharm. Sci. 50, 874–875.PubMedCrossRefGoogle Scholar
  52. Hildebrand, R. (1983) Polymers release drugs continually. High Technol. 3 (1), 10–13.Google Scholar
  53. Hixson, A. W. and Crowell, J. H. (1931a) Dependence of reaction velocity upon surface and agitation. I. Theoretical Considerations. Indust. Engineer. Chem. 23, 923–931.CrossRefGoogle Scholar
  54. Hixson, A. W. and Crowell, J. H. (1931b) Dependence of reaction velocity upon surface and agitation. II. Experimental procedure in study of surface. Indust. Engineer. Chem. 23, 1002–1009.CrossRefGoogle Scholar
  55. Hopfenberg. H. B. (1976) Controlled Release From Erodible Slabs, Cylinders and Spheres, in Controlled Release Polymeric Formulations (Paul, D. R. and Harris, F. W., eds.) ACS Symposium Series 33, American Chemical Society, Washington, DC.Google Scholar
  56. Horbett, T. A., Kost, J., and Ratner, B. D. (1983) Swelling behavior of glucose sensitive membranes. Polymer Preprints 24 (1), 34–35.Google Scholar
  57. Horbett, T. A., Ratner, B. D., Kost, J., and Singh, M. (1984) A Bioresponsive Membrane for Insulin Delivery, in Recent Advances in Drug Delivery Systems ( Anderson, J. M. and Kim, S. W., eds.) Plenum, New York.Google Scholar
  58. Hudson, J. L. and Wagner, J. F. (1980) Remarkable drug implant. US Patent 4,191, 741.Google Scholar
  59. Hyman, S., Bernstein, B. S., and Kapoor, R. C. (1972) US Patent 3, 705, 938.Google Scholar
  60. Inhler, D. M. (1979) Potential Use of Erythrocytes as Carriers for Enyzmes and Drugs, in Drug Carriers in Biology and Medicine ( Gregoriadis, G., ed.) Academic, London.Google Scholar
  61. Inhorn, M. C. (1981) New dimensions in drug delivery. Drug Topics August 7, 38–50.Google Scholar
  62. Jeong, S. Y., Sato, S„ McRea, J. C., and Kim, S. W. (1983) Controlled release of bioactive glycosylated insulins. 10th International Symposium on Controlled Release of Bioactive Materials San Francisco, California, July 24 - 27.Google Scholar
  63. Karim, A. (1983) Transdermal absorption of nitroglycerin from microseal drug delivery (MDD) system. Angiology 34 (1), 11–22.PubMedCrossRefGoogle Scholar
  64. Kath, G. S., Egerton, J. R., and Geiger, R. (1985) In-dwelling ruminor eticulum bolus radiobeacon. Am. J. Vet. Res. 46, 1362013137.Google Scholar
  65. Katz, I. M. and Blackman, W. M. (1977) A soluble sustained-release opthalmic delivery unit. Am. J. Ophthalmol 83, 728.PubMedGoogle Scholar
  66. Keith. A. and Snipes, W. (1980) European Patent Application 0013 606A2.Google Scholar
  67. Kim, S. W. (1983) Hvdrogels as drug delivery systems. Pharm. Int. April, 90 - 91.Google Scholar
  68. Kim, S. W„ Jeong, S. Y„ Sato, S., McRca, J. C., and Feijen, J. (1984) Self- Regulating Insulin Delivery System—A Chemical Approach, in Recent Advances in Drug Delivery Systems ( Anderson, J. M. and Kim, S. W., eds.) Plenum, N.Y.Google Scholar
  69. Kimelberg, H. K. (1976) Differential distribution of liposome entrapped (3H)-methotrexate and labeled lipids after intravenous injeciton in a primate. Biochim. Biophys. Acta 448. 531–550.PubMedCrossRefGoogle Scholar
  70. Koestler, R. C. (1980) Microencapsulation by Interfacial Polymerization Techniques-Agricultural Applications, in Controlled Release Technologies: Methods, Theory and Applications vol. II ( Kvdonieus, A. F., ed.) CRC, Boca Raton, Florida.Google Scholar
  71. Korsmeyer, R. W. and Peppas, N. A. (1983) Macromolecular and Modeling Aspects of Swelling Controlled Systems, in Controlled Release Delivery Systems ( Roseman, T. J. and Mansdorf, S. Z., eds.) Marcel Dekker, New York.Google Scholar
  72. Kost, J. and Langer, R. (1984) Controlled release of bioactive agents. Trends Biochem. 2 (2), 47–51.Google Scholar
  73. Kreuter, J. (1978) Nanoparticles and nanocapsules—New dosage forms in the nanometer range. Pharm. Acta Helv. 53. 33–39.PubMedGoogle Scholar
  74. Kydonieus, A. (1980) Fundamental Concepts of Controlled Release, in Controlled Release Technologies: Methods, Theory and Applications vol. I ( Kydonieus, A., ed.) CRC, Boca Raton, Florida.Google Scholar
  75. Laby, R. H. (1974) Device for administration to ruminants. US Patent 3,844, 285.Google Scholar
  76. Laby, R. H. (1978) Australian Patent Application 35908/78.Google Scholar
  77. Laby, R. H. (1982) Controlled release compositions for administration of therapeutic agents to ruminants. Australian Patent PCTAU80/ 00082.Google Scholar
  78. Lachman, L., Lieberman, H. A., and Kanig, J. L., eds. (1976) The Theory ami Practice of Industrial Pharmacy 2nd Ed. Lea & Febiger, Philadelphia, Pennsylvania.Google Scholar
  79. Lee, E. S., Kim, S. W., Kim, S. H., Cardinal, J. R., and Jacobs, H. (1980) Drug release from hydrogel devices with rate controlling barriers. J. Membr. Sci. 7, 293.CrossRefGoogle Scholar
  80. Lebane, L. (1982) Controlled-release capsules for improving herd health. Rural Res. 115, 10–14.Google Scholar
  81. Lieberman, 11. A. and Lachman, L., eds. (1980) Pharmaceutical Dosage Form: Tablets vols. 1 - 3, Marcel Dekker, New York.Google Scholar
  82. Lipowski, A. (1948) Australian Patent 109, 438.Google Scholar
  83. Lipper, R. A. and Higuchi, W. I. (1977) Analyses of theoretical behavior of a proposed zero-order drug delivery system. J. Pharm. Sci. 66. 163–164.PubMedCrossRefGoogle Scholar
  84. Long, D. M., Jr., and Folkman, J. (1966) Polysiloxane carrier for controlled release of drugs and other agents. US Patent 3,279, 996.Google Scholar
  85. Madan, P. L. (1983) Sustained-release drug delivery systems. 1. An overview. Pharm. Manu. February, 23–27.Google Scholar
  86. McClure, W. O. and Stoughton, R. B. (1982) Enhancement of transdermal drug administration-Azone, presented at Industrial Pharmaceutical R&D Symposium on Transdermal Controlled Release Medication Rutgers University, College of Pharmacy, Piscataway, New Jersey, January 14–15.Google Scholar
  87. Michaels, A. S. (1974) Drug delivery device with self actuated mechanism for retaining device in selected area. US Patent 3,786, 813.Google Scholar
  88. Michaels, A. S., Bashwa, J. D., Zaffaroni, A. (1975) Integrated device for administering beneficial drug at programmed rate. US Patent 3,901, 232.Google Scholar
  89. Miller, A. and Morales, J. G. (1976) Non-volatile slow release pesticidal generators. US Patent 3,944, 662.Google Scholar
  90. Miller, J. E., Baker, N. F., and Colburn, E. L. (1977) Insecticidal activity of propoxur- and carbarvl-impregnated flea collars against Ctenocephalides felis. Am.J. Vet Res. 38 923–925.Google Scholar
  91. Moo-Young, A. J., Tatum, H.L., Wan, L. S., and Lane, M. E. (1975) Copper Levels in Certain Tissues of Rhesus Monkeys and of Women Bearing Copper IUD’s, in Anal. Intrauterine Contracept., Proceedings of the International Conference 3rd (1974), ( Hefnawi, F. and Segal, S. J., eds.) Elsevier, New York.Google Scholar
  92. Nash, H. A. (1984) Controlled Release Systems for Contraception, in Medical Application of Controlled Release vol. II ( Langer, R. S. and Wise, D. L., eds.) CRC, Boca Raton, Florida.Google Scholar
  93. Osol, A. and Farrar, G. E., eds. (1947) The Dispensatory of the United States of America Lippincott, Philadelphia, Pennsylvania, p. 1178.Google Scholar
  94. Peppas, N. A. (1984) Mathematical Modeling of Diffusion Processes in Drug Delivery Systems, in Controlled Drug Bioavailability vol. I Drug Product Design and Performance ( Smolen, V. F. and Ball, L. A., eds.) John Wiley, New York.Google Scholar
  95. Pope, D. G. (1978) Animal Health Specialized Delivery Systems, in Animal Health Products Design and Evaluation ( Monkhouse, D. C., ed.) American Pharmaceutical Association, Washington, DC.Google Scholar
  96. Pope, D. G. (1983) Specialized Dose Dispensary Equipment, in Formulation of Veterinary Dosage Forms ( Blodinger, J., ed.) Marcel Dekker, New York.Google Scholar
  97. Pope, D. C., Wilkinson, P. K., Egerton, J. R„ and Conroy, J. (1985) Oral controlled release delivery of invermectin in cattle via an osmotic pump. J. Pharm. Sci. 74, 1108–1110.PubMedCrossRefGoogle Scholar
  98. Prestele, K., Franetzki, M. and Kreese, H. (1980) Development of program controlled portable insulin delivery devices. Diabetes Care 3, 362–370.PubMedCrossRefGoogle Scholar
  99. Quick, 11. L. (1971) Clinical evaluation of a free-hanging 20% dichlorvos (DDVP) disc for control of flea infestation of dogs. Vet. Med. 66, 773–774.Google Scholar
  100. Raghunatha, Y. (1980) US Patent 9, 221, 778.Google Scholar
  101. Rahman, Y. E., Rosenthal, M. W., and Cerny, E. A. (1973) Intracellular plutonium removal by liposome-encapsulated chelating agent. Science 180, 300–302.PubMedCrossRefGoogle Scholar
  102. Rhine, W„ Sukhatme, V., Hsieh, D. S. T., and Langer, R. S. (1980) A New Approach to Achieve Zero-Order Release Kinetics From Diffusion-Controlled Polymer Matrix Systems, in Controlled Release of Bioactive Materials ( Baker, R., ed.) Academic, New York.Google Scholar
  103. Riner, J. L. (1982) Sustained release ruminant boluses and factors determining their release rates. Doctoral dissertation, Oklahoma State University.Google Scholar
  104. Riner, J. L., Byford, R. L„ Stratton, L. G., and Hair, J. A. (1982) Influence of density and location on degradation of sustained-release boluses given to cattle. Am. J. Vet. Res. 43. 2028–2030.PubMedGoogle Scholar
  105. Robertson, D. N. (1983) Release rates of levonorgestrel from silastic capsules, homogeneous rods and covered rods in humans. Contraception 27, 483.PubMedCrossRefGoogle Scholar
  106. Robertson, D. N. (1985) Contraception with long-acting subdermal implants. A five-year clinical trial with silastic covered rod implants containing levonorgestrel. Contraception 31, 351.PubMedCrossRefGoogle Scholar
  107. Roche, E. B., ed. (1977) Biopharmaceutical properties of drugs in design of biopharmaceutical properties through prodrugs and analogs. American Pharmaceutical Association. Washington, DC.Google Scholar
  108. Rogers, J. A. (1982) Recent developments in drug delivery. Can. J. Hosp. Pharm. 25 (6), 170–196.Google Scholar
  109. Roseman, T. J. and Yalkowsky, S. H. (1976) Importance of Solute Partitioning on the Kinetics of Drug Release From Matrix Systems, in Controlled Release Polymeric Formulations (Paul, D. R. and Haris, F. W., eds.) ACS Symposium Series 33, American Chemistry Society, Washington, DC.CrossRefGoogle Scholar
  110. Schor, J. M. (1982) US Patent 4, 357, 469.Google Scholar
  111. Schor, J. M. and Nigalye, A. (1983) US Patent 4, 389, 383.Google Scholar
  112. Sefton, M. V., Allen, D. G., Horvath, V., and Zingg, W. (1984) Insulin Delivery at Variable Rates From a Controlled Release Micropump, in Recent Advances in Drug Delivery System ( Anderson, J. M. and Kim, S. W., eds.) Plenum. New York.Google Scholar
  113. Senyei, A. E., Driscoll, C. F., and Widder, K. J. (1985) Biophysical drug targeting—magnetically responsive albumin microspheres. Meth. Enzymol. 112, 56–67.PubMedCrossRefGoogle Scholar
  114. Shell, J. W. (1985) Opthalmic drug delivery systems. Drug Dev. Res. 6. 345–261.CrossRefGoogle Scholar
  115. Sherwin, R. S., Schulman, G. A., Hendler, R., Walesky, M„ Belous, A., and Tamborlane, W. (1983) Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man. Diabetologia 24 (3) 155–161.PubMedCrossRefGoogle Scholar
  116. Sheth, P. R. and Tossounian, J. L. (1978) Hoffman-La Roche US Patent 4, 126, 672.Google Scholar
  117. Stoughton, R. B. (1982) Enhanced percutaneous penetration with 1-do- decylazacycloheptan-2-one(Azone). Arch. Dermatol. 118, 474–480.PubMedCrossRefGoogle Scholar
  118. Sugibayashi, K., Morimoto, Y., Nadai, T., Kato, Y., Hasegawa, A., and Arita, T. (1979) Drug-carrier property of albumin microspheres in chemotherapy. II. Preparation and tissue distribution in mice of microsphere-entrapped 5-fluorouracil. Chem. Pharm. Bull. 27, 204– 209.Google Scholar
  119. Theeuwes, F. (1980a) US Patent 4,235,236, November 25.Google Scholar
  120. Theeuwes, F. (1980b) Delivery of Drugs by Osmosis, in Controlled Release Technologies: Methods, Theory and Applications vol. II ( Kvdonieus, A., ed.) CRC, Boca Raton, Florida.Google Scholar
  121. Theeuwes, F. (1982) US Patent 4, 309, 996.Google Scholar
  122. Theeuwes, F. and Bayne, W. (1981) Controlled-Release Dosage Form Design, in Controlled Release Pharmaceuticals (Urquhart,J., ed.) American Pharmaceutical Association, Washington, DC.Google Scholar
  123. Thombre, A. G., Zentner, Z. M., and Himmelstein, K. S. (1985) Mechanism of Transport Kinetics in a Controlled Porosity Osmotic Pump, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials. Geneva, Switzerland.Google Scholar
  124. Tindall, B. (1983) Implants and growth promotion. Anim. Nutrit. Health Sept.-Oct., 14–20.Google Scholar
  125. Tojo, K. (1984) Prolonged drug release from a cylindrical matrix device with a small release hole. Chem. Eng. Commun. 30. 311–322.CrossRefGoogle Scholar
  126. Tomlinson, E. and Davis, S. S. (1986) Site-Specific Drug Delivery Wiley, New York.Google Scholar
  127. Tyrrell, D. A., Heath, T. D., Colley, C. M. and Ryman, B. E. (1976) New aspects of liposomes. Biochim. Biophys. Acta 457. 259–302.PubMedGoogle Scholar
  128. University of Glasgow (1984) Device for introducing nutrients and/or therapeutic materials into ruminant animals. European Patent 97 - 507a.Google Scholar
  129. Urquhart, J., Chandrasekaran, S. K., and Shaw, J. E. (1977) US Patent 4,031,894, June 18.Google Scholar
  130. Watanabe, S., Kayamo, M., Ishino, Y., and Miyao, K. (1976) Solid therapeutic preparation remaining in stomach. US Patent 3,976, 764.Google Scholar
  131. Welling, P. G. (1983) Oral controlled drug administration, Drug. Devel. Indust. Pharm. 9 (7), 1185–1225.CrossRefGoogle Scholar
  132. Wise, D. L.. (1984) Controlled Release for Use in Treatment of Narcotic Addiction, in Medical Applications of Controlled Release vol. II ( Larver, R. S. and Wise, D. L., eds.) CRC, Boca Raton, Florida.Google Scholar
  133. Wright, C. 1.., Titchener, R. N., and Hughes, J. (1984) Insecticidal ear tags and spravs for the control of fleas on cattle. Vet. Record 115, 60–63.CrossRefGoogle Scholar
  134. Yolles, S., Eldridge, J. E., and Woodland, J. H. R. (1971) Sustained delivery of drugs from polymer/drug mixtures. Polymer News 1, 9.Google Scholar
  135. Yolles, S. and Sartori, M. F. (1980) Erodible Matrices, in Controlled Release Technologies: Methods, Theory, and Applications vol. II ( Kydonieus, A. F., ed.) CRC, Boca Raton, Florida.Google Scholar
  136. Zaffaroni, A. (1980) The innovators-delivering drugs. Chemtech. February, 82–88.Google Scholar
  137. Zentner, G. (1985) Osmotic flow through controlled porosity films: An approach to delivery of water soluble compounds. Second International Symposium on Recent Advances in Drug Delivery Systems. Salt Lake City, Utah, February 27–March 1.Google Scholar

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  • Joseph V. Bondi
  • D. G. Pope

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