Toxicological Evaluation of Drugs
All drugs have the potential to produce toxicity. The degree to which such toxicity occurs in a compound as balanced against its therapeutic activity is termed the therapeutic index. Toxicity should be clearly dissociable from efficacy. The goal of toxicity testing is therefore to determine the adverse effects of drugs in well- defined biological systems, which have their own unique susceptibility to toxicity. Once determined, these effect(s) of a drug and its metabolites are extrapolated to humans so that potential risks can be weighed against potential benefits. The ultimate objective is to evaluate the probability that a drug will not produce significant damage under specific conditions of use (Health and Welfare, Canada, 1981).
KeywordsThymidine Kinase Good Laboratory Practice Acute Toxicity Study Chronic Study Toxicological Evaluation
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