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The Glucagon Genes

  • Chapter
Molecular Cloning of Hormone Genes

Part of the book series: Molecular Biology and Biophysics ((MBB))

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Abstract

Glucagon is a peptide hormone of 29 amino acids produced and secreted by the A cells of the pancreatic islets (1). It is a member of a structurally related group of peptides that includes secretin (2), vasoactive intestinal peptide (3), gastric inhibitory peptide (4), and growth hormone releasing hormone (5) (Fig. 1). The secretion of glucagon is regulated by blood levels of glucose (6) and amino acids (7), as well as by a variety of hormonal stimuli (8). The action of glucagon on its target tissues, particularly the liver, is an important factor in protein and carbohydrate metabolism (9,10). Abnormal regulation of glucagon gene expression has been implicated in the pathogenesis of diabetes mellitus (11).

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Authors
  1. Gerhard Heinrich
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  2. Joel F. Habener
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Editor information

Editors and Affiliations

  1. Laboratory of Molecular Endocrinology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joel F. Habener

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© 1987 The Humana Press Inc.

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Heinrich, G., Habener, J.F. (1987). The Glucagon Genes. In: Habener, J.F. (eds) Molecular Cloning of Hormone Genes. Molecular Biology and Biophysics. Humana Press. https://doi.org/10.1007/978-1-4612-4824-8_4

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  • DOI: https://doi.org/10.1007/978-1-4612-4824-8_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9178-7

  • Online ISBN: 978-1-4612-4824-8

  • eBook Packages: Springer Book Archive

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