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Gene Structure and Regulation

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Book cover Molecular Cloning of Hormone Genes

Part of the book series: Molecular Biology and Biophysics ((MBB))

Abstract

The polypeptide hormones are a diverse group of small proteins, approximately 50 in number, ranging in size from three to 300 amino acids, that regulate the processes of metabolism, reproduction, growth, and development (1). In the broad sense, however, many of these polypeptides can be considered regulatory peptides because they serve not only as hormones in which their actions are mediated on target organs by way of their transport through the bloodstream, but also as local cell-to-cell communicators. The designation of the term hormones to certain of these polypeptides is a consequence of the initial physiologic observations that they are products of specific organs and endocrine glands, and are released into the bloodstream to exert their actions on distant target organs. The products of the actions of the hormones in turn regulate (often inhibit) the further production of the specific hormones.

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References

  1. Habener J. F. (1985) Genetic Control of Hormone Formation in Textbook of Endocrinology (Wilson J. and Foster D., eds.), Saunders, Philadelphia.

    Google Scholar 

  2. Banting Best C. H., Collip J. B., Macleod J., Jr., and Noble E. C. (1933) The effect of pancreatic extract (insulin) on normal rabbits. Am. J. Physiol. 62, 162–176.

    Google Scholar 

  3. Scharrer E. and Scharrer B. (1940) Secretory Cell Within the Hypothalamus, in The Hypothalamus (Assoc. Research in New Mental Disease) Hafner, New York.

    Google Scholar 

  4. Krieger D. T. (1983) Brain peptides: What, where and why Science 222, 975–985.

    Article  PubMed  CAS  Google Scholar 

  5. Reichlin S. (1983) Somatostatin. N. Eng. J. Med. 309, 1501–1563.

    Article  Google Scholar 

  6. Habener J. F. (1985) Neuropeptides in Lower Forms of Life, in Bioenergetics of Neurohormonal Peptide ( Hakanson R. and Thornell H., eds.), Academic, New York.

    Google Scholar 

  7. Kurjan J. and Herskowitz I. (1982) Structure of a yeast pheromone gene (MFx): A putative a factor precursor contains four tandem copies of mature a factor. Cell 30, 933–943.

    Article  PubMed  CAS  Google Scholar 

  8. Loumave E., Thorner J., and Catt K. J. (1982) Yeast-mating pheromone activates mammalian gonadotrophs: Evolutionary conservation of a reproductive hormone. Science 218, 1323–1325.

    Article  Google Scholar 

  9. Popenos N. A. and duVigneaud V. (1954) A partial sequence of amino acids in performic acid-oxidized vasopressin. J. Biol. Client. 205, 353–360.

    Google Scholar 

  10. Pierce J. G. and duVigneaud V. (1950) Preliminary studies on amino acid content of a high-potency preparation of the oxytocic hormone of the posterior lobe of the pituitary gland. J. Biol. Chem. 182, 359–366.

    CAS  Google Scholar 

  11. Ullrich A., Shine J., Chirgwin J., Pictet R., Tischer E., Rutter W. J., and Goodman H. M. (1977) Rat insulin genes: Construction of plasmids containing the coding sequence. Science 196, 1313–1319.

    Article  PubMed  CAS  Google Scholar 

  12. Seeburg P. H., Shine J., Martial J. A., Baxter J. D., and Goodman H. M. (1977) Nucleotide sequence and amplification in bacteria of the structural gene for rat growth hormone. Nature 270, 486–494.

    Article  PubMed  CAS  Google Scholar 

  13. Romberg R. D. and Klug A. (1981) The nucleosome. Sci. Am. 244, 52–63.

    Article  Google Scholar 

  14. Sharp P. A. (1981) Speculations on RNA processing. Cell 23, 643–46.

    Article  PubMed  CAS  Google Scholar 

  15. Rogers J. and Wall R. (1980) A mechanism for RNA splicing. Proc. Natl. Acad. Sci. USA 77, 1877–1879.

    Article  PubMed  CAS  Google Scholar 

  16. Nordheim A., Pardue M. L., Lafer E. M., Moller A., Stollar B. D., and Rich A. (1981) Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polvtene chromosomes. Nature 294, 417–422.

    Article  PubMed  CAS  Google Scholar 

  17. Schon E., Evans T., Welsh J., and Efstratiatis A. (1983) Conformation of promoter DNA: Fine mapping of Sl-hvpersensitive sites. Cell 35, 837–848.

    Article  PubMed  CAS  Google Scholar 

  18. Hand A. R., and Oliver C, eds. (1981) Basic Mechanisms of Cellular Secretion. Academic, New York.

    Google Scholar 

  19. Blobel G. (1980) Intracellular protein topogenesis. Proc. Natl. Acad. Sci. USA 77, 1496–1500.

    Article  PubMed  CAS  Google Scholar 

  20. Crick F. (1979) Split genes and RNA splicing. Science 204, 264–271.

    Article  PubMed  CAS  Google Scholar 

  21. Gilbert W. (1978) Why genes in pieces? Nature 271, 501.

    Article  PubMed  CAS  Google Scholar 

  22. Heinrich G., Gros P., and Habener J. F. (1984) Glucagon gene sequences: Four of six genes encode separate functional domains of rat pre-proglucagon. J. Biol. Chem. 259, 14082–14087.

    PubMed  CAS  Google Scholar 

  23. Miller W. and Eberhardt N. L. (1983) Structure and evolution of the growth hormone gene family. Endocr. Rev. 4, 97–130.

    Article  PubMed  CAS  Google Scholar 

  24. J. Südhof T. C., Goldstein J. L., Brown M. S., and Russel D.W. (1985) The LDL receptor gene: A mosaic of exons shared with different proteins. Science 228, 815–822.

    Google Scholar 

  25. Nakanishi S., Inoue A., Kita T., Nakamura M., Chang A. C. Y., Cohen S. N. and Numa S. (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-lipotropin precursor. Nature 278, 423–427.

    Article  PubMed  CAS  Google Scholar 

  26. Noda M., Teranishi Y., Takahashi H., Toyasoto M., Notake M., Nakanishi S., and Numa S. (1982) Isolation and structural organization of the human prepro-enkephalin gene. Nature 297, 431–434.

    Article  PubMed  CAS  Google Scholar 

  27. Perler F., Efstratiadis A., Lomedico P., Gilbert W., Kolodner R., and Dodgson J. (1980) The evolution of genes: The chicken pre- proinsulin gene. Cell 20, 555–565.

    Article  PubMed  CAS  Google Scholar 

  28. Dover G. (1982) Molecular drive: A cohesive mode of species evolution. Nature 299, 111–117.

    Article  PubMed  CAS  Google Scholar 

  29. Calos M. P. and Miller, J. H. (1980) Transposable elements. Cells 20, 579–595.

    Article  CAS  Google Scholar 

  30. Rosenfeld M. G., Mermod J. J., Amara S. G., Swanson L. W., Sawchenko P. E., Rivier J., Vale W. W., and Evans R. M. (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304, 129–136.

    Article  PubMed  CAS  Google Scholar 

  31. Leder P., Max E. E., and Seidman J. F. (1980) The Organization of Immunoglobulin Genes and the Origin of Their Diversity, in Fourth International Congress of Immunology: Immunology 80. ( Fougerau M. and Dausset J., eds.), Academic, London.

    Google Scholar 

  32. Nawa H., Kotani H., and Nakanishi S. (1984) Tissue-specific generation of two preprotachvkinin mRNAs from one gene by alternative RNA splicing. Nature 312, 20–27.

    Article  Google Scholar 

  33. Kitamura N., Takagaki Y., Furuto S., Tanaka T., Nawa H., and Nakanishi S. (1983) A single gene for bovine high molecular weight and low molecular weight kininogens. Nature 305, 545–549.

    Article  PubMed  CAS  Google Scholar 

  34. Spindel E. R., Zilberberg M. D., Habener J. F., and Chin W. W. (1986) Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc. Natl. Acad. Sci. USA 83, 19–23.

    Article  PubMed  CAS  Google Scholar 

  35. Richter K., Kawadshima E., Egger R., and Kreil G. (1981) Biosynthesis of thyrotropin releasing hormone in the skin of Xenopus laevis; partial sequence of the precursor deduced from cloned cDNA. EMBO J. 3, 617–621.

    Google Scholar 

  36. Kurjan J. and Herskowitz I. (1982) Structure of a yeast pheromone gene (MF alpha): A putative alpha-factor. Cell 30, 933–943.

    Article  PubMed  CAS  Google Scholar 

  37. Zakarian S. and Smyth D. G. (1982) Beta-endorphin is processed differentlv in specific regions of rat pituitary and brain. Nature 296, 250–252.

    Article  PubMed  CAS  Google Scholar 

  38. Habener J. F., Lund P. K., and Goodman R. H. (1984) Complementary DNAs Encoding Precursors of Glucagon and Somatostatin, in Biogenetics of Neurolwrmonal Peptides. ( Hakanson R. and Thorell J., eds.), Academic, London.

    Google Scholar 

  39. Darnell J. E. (1982) Variety in the level of gene control in eukaryotic cells. Nature 297, 365–371.

    Article  PubMed  CAS  Google Scholar 

  40. Brown D. D. (1981) Gene expression in eukaryotes. Science 211, 667–674.

    Article  PubMed  CAS  Google Scholar 

  41. Habener J. F. and Jacobs J. W. (1982) Biosynthesis and Control of Secretion of the Calcium-Regulating Peptides, in Endocrinology of Calcium Metabolism ( Parsons, J. A., ed.), Raven, New York.

    Google Scholar 

  42. Itoh N. and Okamoto H. (1980) Translational control of proinsulin synthesis by glucose. Nature 283, 100–102.

    Article  PubMed  CAS  Google Scholar 

  43. Habener J. F. (1981) Regulation of parathyroid hormone secretion and biosynthesis. Ann. Rev. Physiol. 43, 211–223.

    Article  CAS  Google Scholar 

  44. Britten R. J. and Davidson E. H. (1969) Gene regulation for higher cells: A theory. Science 165, 349–357.

    Article  PubMed  CAS  Google Scholar 

  45. Davidson F. H., and Britten R. J. (1979) Regulation of gene expression: Possible role of repetitive sequences. Science 204, 1052–1059.

    Article  PubMed  CAS  Google Scholar 

  46. Schmid C. YV. and Jelinek W. R. (1982) The alu family of dispersed repetitive sequences. Science 216, 1065–1070.

    Article  PubMed  CAS  Google Scholar 

  47. McClintock B. (1951) Cold Spring Harbor Symp. Quant. Biol. 16, 13–47.

    PubMed  CAS  Google Scholar 

  48. Davidson E. H., Jacobs H. T., and Britten R. J. (1983) Very short repeats and coordinate induction of genes. Nature 301, 468–470.

    Article  PubMed  CAS  Google Scholar 

  49. Banerji J., Olson L., and Schaffner W. (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33, 729–774.

    Article  PubMed  CAS  Google Scholar 

  50. Marx J. F. (1983) Immunoglobulin genes have enhancers. Science 221, 735–737.

    Article  PubMed  CAS  Google Scholar 

  51. Wu C. and Gilbert W. (1981) Tissue-specific exposure of chromatin structure at the 5 prime terminus of the rat preproinsulin II gene. Proc. Natl. Acad. Sci. USA 78, 1577–1580.

    Article  PubMed  CAS  Google Scholar 

  52. Razin A. and Riggs A. D. (1980) DNA methylation and gene function. Science 210, 604–610.

    Article  PubMed  CAS  Google Scholar 

  53. Walker M. D., Edlund T., Boulet A. M., and Rutter W. J. (1983) Cell-specific expression controlled by the 5 prime-Hanking region of insulin and chymotrypsin genes. Nature 306, 557–561.

    Article  PubMed  CAS  Google Scholar 

  54. Dynan W. S. and Tjian R. (1983) The promoter-specific transcription factor SP 1 binds to upstream sequences in the SV40 early promoter. Cell 79, 87.

    Google Scholar 

  55. Berk A. J., Lee F., Harrison T., Williams S. J, and Sharp P. A. (1979) Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs. Cell 17, 935.

    Article  PubMed  CAS  Google Scholar 

  56. Persson H. and Leder P. (1984) Nuclear localization and DNA binding of proteins expressed by human C-mvc oncogene. Science 225, 718–721.

    Article  PubMed  CAS  Google Scholar 

  57. Ralston R. and Bishop J. M. (1983) The protein products of the myc and myb oncogenes and adenovirus Ela are structurally related. Nature 306, 803.

    Article  PubMed  CAS  Google Scholar 

  58. Borrelli E., Hen R., and Chambon P. (1984) Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription. Nature 312, 608–612.

    Article  PubMed  CAS  Google Scholar 

  59. Gidoni D., Dynan W. S., and Tjian R. (1984) Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature 312, 409–413.

    Article  PubMed  CAS  Google Scholar 

  60. Cohen P. (1982) The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature 296, 613–620.

    Article  PubMed  CAS  Google Scholar 

  61. Chan L. and O’Malley B. W. (1976) Mechanism of action of the sex steroid hormones. N. Eng. J. Med. 294, 1322–1437.

    Article  CAS  Google Scholar 

  62. O’Malley B. (1984) Steroid hormone action in eukaryotic cells. J. Clin. Invest. 74, 307–312.

    Article  PubMed  Google Scholar 

  63. Murdoch G. H., Franco R., Evans K. M., and Rosenfeld M. G. (1983) Polypeptide hormone regulation of gene expression. J. Biol. Chew. 258, 15329–15336.

    CAS  Google Scholar 

  64. Rubin R. P. (1970) The role of calcium in the release of neurotransmitter substances and hormones. Phar. Rev. 22, 389.

    CAS  Google Scholar 

  65. Baxter J. D. and Ivarie R. D. (1978) Regulation of gene expressed by glucocorticoid hormones: Studies of receptors and responses in culturcd cells. Receptors in Hormone Action 2, 251–284.

    CAS  Google Scholar 

  66. Compton J. G., Schrader W. T., and O’Malley B. W. (1983) DNA sequence preference of the progesterone receptor. Proc. Natl. Acad. Sci. USA 80, 16–20.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Joel F. Habener
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joel F. Habener

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© 1987 The Humana Press Inc.

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Habener, J.F. (1987). Gene Structure and Regulation. In: Habener, J.F. (eds) Molecular Cloning of Hormone Genes. Molecular Biology and Biophysics. Humana Press. https://doi.org/10.1007/978-1-4612-4824-8_2

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  • DOI: https://doi.org/10.1007/978-1-4612-4824-8_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9178-7

  • Online ISBN: 978-1-4612-4824-8

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