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The Use of Disulfiram

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Alcoholism

Part of the book series: Frontiers of Primary Care ((PRIMARY))

Abstract

Disulfiram is a drug commonly used as a deterrent to drinking because of the unpleasant physiologic responses it induces in the presence of alcohol. It has a definite, albeit limited, role in the treatment of alcoholic patients. Several hundred thousand abstinent patients take the drug daily to help overcome the impulse to drink alcohol.1

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References

  1. Fried R: Comments on Antabuse therapy in alcoholism (Letter). Alcoholism 1977;1:275.

    PubMed  CAS  Google Scholar 

  2. Kwentus J, Major LF: Disulfiram in the treatment of alcoholism. J Stud Alcohol 1979;40:428–446.

    PubMed  CAS  Google Scholar 

  3. Ritchie JM: The aliphatic alcohols, in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics, ed 5. New York, Macmillan, 1975, pp 148–149.

    Google Scholar 

  4. Editors: Disulfiram (Antabuse). Medical Letter. New Rochelle, NY, 1980;22(1):1.

    Google Scholar 

  5. Child GP, Osinski W, Bennett RE, Davidoff E: Therapeutic results and clinical manifestations following the use of tetraethylthiuram disulfide (Antabuse). Am J Psychiatry 1951;107:774–780.

    PubMed  CAS  Google Scholar 

  6. McCabe ES, Wilson WW: Dangerous cardiac effects of tetraethylthiuram disulfide (Antabuse) therapy in alcoholism.Arch Intern Med 1954;94:259–263.

    CAS  Google Scholar 

  7. Sellars EM, Naranjo CA, Peachey JE: Drugs to decrease alcohol consumption. N Engl J Med 1981;305:1255–1261.

    Article  Google Scholar 

  8. Petroni NC, Cardoni AA: Alcohol content of liquid medicinals. Clin Toxicol 1979;14:407–432.

    Article  PubMed  CAS  Google Scholar 

  9. Major LF, Goyer PF: Effects of disulfiram and pyridoxine on serum cholesterol. Ann Intern Med 1978;88:53–56.

    PubMed  CAS  Google Scholar 

  10. Reisberg B: Catatonia associated with disulfiram therapy. J Nerv Ment Dis 1978; 166:607–609.

    Article  PubMed  CAS  Google Scholar 

  11. Nora AH, Blu J: Limb-reduction anomalies in infants born to disulfiram-treated alcoholic mothers (Letter). Lancet 1977;2:664.

    Article  PubMed  CAS  Google Scholar 

  12. Seixas FA: Alcohol and its drug interactions. Ann Intern Med 1975;83:86–92.

    PubMed  CAS  Google Scholar 

  13. Beach CA, Mays DC, Guiter RC, et al: Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39: 265–270.

    Article  PubMed  CAS  Google Scholar 

  14. Wallerstein RS: Psychologic factors in chronic alcoholism. Ann Intern Med 1958;48:114–122.

    PubMed  CAS  Google Scholar 

  15. Lundwall L, Baekeland F: Disulfiram treatment of alcoholism: A review. J Nerv Ment Dis 1971;153:381–394.

    Article  PubMed  CAS  Google Scholar 

  16. Weisman MN: The use of disulfiram in the treatment of alcoholism. Md State Med J 1968;17:83–84.

    PubMed  CAS  Google Scholar 

  17. Fuller RK, Williford WO: Life-table analysis of abstinence in a study evaluating the efficacy of disulfiram. Alcoholism 1980;4:298–301.

    PubMed  CAS  Google Scholar 

  18. Fuller RK, Branchey L, Brightwell DR, et al: Disulfiram treatment of alcoholism: a Veteran’s Administration cooperative study. JAMA 1986;250(11): 11449–1455.

    Google Scholar 

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© 1987 Springer-Verlag New York Inc.

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Barnes, H.N. (1987). The Use of Disulfiram. In: Barnes, H.N., Aronson, M.D., Delbanco, T.L. (eds) Alcoholism. Frontiers of Primary Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4786-9_8

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  • DOI: https://doi.org/10.1007/978-1-4612-4786-9_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9155-8

  • Online ISBN: 978-1-4612-4786-9

  • eBook Packages: Springer Book Archive

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