Studies on Biochemical Mechanisms of Retinal Degeneration
Our laboratory is investigating biochemical mechanisms of certain forms of retinal degeneration which specifically affect the photoreceptor cells. One experimental model we use is the albino or pigmented rat retina exposed to constant illumination. Our strategy has been to expose animals to moderate light levels for periods up to five days and analyze for changes in the components of the photoreceptor rod outer segments (ROS) that may result from or contribute to the observed degeneration. Results obtained to date suggest that lipid peroxidation occurs within ROS membranes during light-induced retinal degeneration. In this chapter, we will review briefly results of some of our studies and propose a means by which photoreceptors are protected against lipid peroxidation. Other reviews on this subject have been published by our group (Anderson, et al., 1983; Wiegand, et al., 1984).
KeywordsLipid Peroxidation Outer Segment Ferrous Sulfate Photoreceptor Cell Lipid Hydroperoxide
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