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Receptor-Mediated Action of the Vitamin D Hormone

  • Conference paper
Gene Regulation by Steroid Hormones III

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Abstract

1,25-Dihydroxyvitamin D3(1,25(OH)2D3) is now considered to be the active hormonal sterol derived from the sunlight vitamin, vitamin D3. As depicted in Fig. 1, 1,25(OH)2D3 is formed in the kidney according to the calcium and phosphorus needs of the organism (Haussler and McCain, 1977). Its main functions are the stimulation of intestinal calcium and phosphate absorption as well as bone remodeling. In addition to its mineral conservation effects in the kidney, 1,25(OH)2D3 induces a 24-OHase enzyme that appears to initiate a catabolic cascade for side chain cleavage and metabolic elimination of both the hormone (Fig. 1) and its 25(OH)D3 precursor (Chandler et al., 1984). Thus the 1,25(OH)2D3 hormone is dynamic in the sense that its production is controlled by calcium/parathyroid hormone (PTH) and phosphate status, and its biodegradation is self-initiated.

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Authors
  1. M. R. Haussler
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  2. D. J. Mangelsdorf
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  3. C. A. Donaldson
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  4. S. L. Marion
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  5. N. M. Sleator
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  6. J. W. Pike
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Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Oakland University, 48063, Rochester, Michigan, USA

    Arun K. Roy

  2. Department of Cell Biology, Baylor College of Medicine, 77030, Houston, Texas, USA

    James H. Clark

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© 1987 Springer-Verlag New York Inc.

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Haussler, M.R., Mangelsdorf, D.J., Donaldson, C.A., Marion, S.L., Sleator, N.M., Pike, J.W. (1987). Receptor-Mediated Action of the Vitamin D Hormone. In: Roy, A.K., Clark, J.H. (eds) Gene Regulation by Steroid Hormones III. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4686-2_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4686-2_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9114-5

  • Online ISBN: 978-1-4612-4686-2

  • eBook Packages: Springer Book Archive

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