Intra- and Intercellular Aspects of the Hormonal Regulation of α2u-Globulin Gene Expression

  • A. K. Roy
  • F. H. Sarkar
  • C. V. R. Murty
  • D. Majumdar
  • W. F. Demyan
Conference paper

Abstract

Initial studies of Jensen and Jacobsen (1962), followed by results from many other laboratories, have led to the emergence of the present concept of molecular mechanism of hormone action whereby steroid hormones can ultimately influence gene expression by site-specific receptor-DNA interaction (Payvar et al., 1981). Using various model systems, most of the investigators have come to the conclusion that steroid hormones generally regulate cell functions through pretranslational regulation of target gene transcription. All of these conceptual models are based on the effect of one particular steroid hormone on a specific cell type. However, recent results from several sources have indicated the important, and in some cases critical, role of multicellular interactions in the mediation of hormone action (Kratochwil, 1969; Sakakura et al., 1976; Cunha et al., 1983). Initial studies in our laboratory were directed to explore the molecular mechanism of steroidal regulation of α2u-globulin synthesis in the rat liver. Further studies of the α2u-globulin model led to the appreciation of the multihormonal regulation of α2u-globulin gene expression (Roy, 1979; Roy et al., 1983). In this chapter we highlight recent results from our laboratory which indicate that the tissue architecture and cell-cell interactions can profoundly influence the ultimate hormone responsiveness in the regulation of α2u-globulin gene expression.

Keywords

Estrogen Glucocorticoid Androgen Peri Sorting 

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References

  1. Antalky T, Lynch KR, Nakhasi HL, Feigelson P (1982) Am J Anat 165: 211–224CrossRefGoogle Scholar
  2. Brock ML, Shapiro DJ (1983) Cell 34: 207–224PubMedCrossRefGoogle Scholar
  3. Colburn P, Buonassisi V (1978) Science 201: 817–819PubMedCrossRefGoogle Scholar
  4. Cunha GR, Chung LWK, Shannon JM, Reese BA (1980) Biol Reprod 22: 19–42PubMedCrossRefGoogle Scholar
  5. Cunha GR, Chung LWK, Shannon JM, Taguchi O, Hirohiko F (1983) Recent Prog Horm Res 39: 559–598PubMedGoogle Scholar
  6. Greengard O, Federman M, Knox WE (1972) J Cell Biol 52: 261–272PubMedCrossRefGoogle Scholar
  7. Jensen EV, Jacobsen HJ (1962) Recent Prog Horm Res 18: 387–414Google Scholar
  8. Jungermann K, Sasse D (1978) Trends Biochem Sci 3: 198–200CrossRefGoogle Scholar
  9. Kratochwil K (1969) Dev Biol 20: 46–71PubMedCrossRefGoogle Scholar
  10. Kratochwil K, Schwartz P (1976) Proc Natl Acad Sci USA 73: 4041–4044PubMedCrossRefGoogle Scholar
  11. Kurtz DT (1981) J Mol Appl Gen 1: 29–38Google Scholar
  12. Linser P, Moscona AA (1982) In: Moscona AA, Monroy A (eds) Current Topics in Developmental Biology Academic Press, New York. pp 115–188Google Scholar
  13. McGill HC, Sheridan PJ (1981) Circ Res 48: 238–244PubMedGoogle Scholar
  14. Motwani NM, Caron D, Demyan WF, Chatterjee B, Hunter S, Poulik MD, Roy AK (1984) J Biol Chem 259: 3653–3657PubMedGoogle Scholar
  15. Payvar F, Wrange O, Carlsedt-Duke J, Okret S, Gustafsson J, Yamamoto K (1981) Proc Natl Acad Sci USA 78: 6628–6632PubMedCrossRefGoogle Scholar
  16. Roy AK (1973) J Endocrinol 56: 295–301PubMedCrossRefGoogle Scholar
  17. Roy AK (1979) Biochem Act Horm 6: 481–517Google Scholar
  18. Roy AK, Chatterjee B, Demyan WF, Milin BS, Motwani NM, Nath TS, Schiop MJ (1983). Recent Prog Horm Res 39: 425–461PubMedGoogle Scholar
  19. Roy AK, Chatterjee B, Prasad MSK, Unakar NJ (1980) J Biol Chem 255: 11614–11618PubMedGoogle Scholar
  20. Roy AK, McMinn D, Biswas NM (1975) Endocrinology 97: 1501–1508PubMedCrossRefGoogle Scholar
  21. Roy AK, Nath TS, Motwani NM, Chatterjee B (1983) J Biol Chem 258: 10123PubMedGoogle Scholar
  22. Roy AK, Neuhaus OW, Harmison CR (1966) Biochim Biophys Acta 127: 72–81PubMedGoogle Scholar
  23. Sakakura T, Nishizuka Y, Dawe EJ (1976) Science 194: 1439–1441PubMedCrossRefGoogle Scholar
  24. Sirbasku DA (1981) Branbury Report 8: 425–443Google Scholar
  25. Spolski RJ, Schneider W, Wangh LJ (1985) Dev Biol 108: 332–340PubMedCrossRefGoogle Scholar
  26. Stumpf WE, Sar M (1976) In: JR Pasqualini (ed) Receptors and Mechanism of Action of Steroid Hormones, Part 1. Marcel-Dekker, New York. pp 41–84Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • A. K. Roy
  • F. H. Sarkar
  • C. V. R. Murty
  • D. Majumdar
  • W. F. Demyan

There are no affiliations available

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