Abstract
Physiological and synthetic androgens bring about their actions in murine kidney via androgen receptor-mediated mechanisms in a fashion similar to that of other steroid hormones through their respective receptor proteins in a variety of target tissues. Unlike some other steroid-responsive tissues or cell lines, in which large amounts of a few proteins are induced (O’Malley and Means, 1974; O’Malley et al., 1979; Tata and Smith, 1979), androgen action in mouse kidney involves induction of many proteins that are of low abundancy, with none predominating as a percentage of total protein concentration. For example, two-dimensional gel electrophoretic analysis of soluble renal proteins could not reveal any major differences in their profile in untreated and androgen-induced mice (Swank et al., 1978). These considerations, along with well-established mouse genetics, render the murine kidney an attractive model system to study steroid hormone action and, in particular, to investigate regulation of a number of gene products within a single cell type and by a single steroid hormone.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Atmar VJ, Kuehn GD (1981) Proc Natl Acad Sci USA 78:5518–5522
Bardin CW, Catterall JF (1981) Science 211: 1285–1294
Berger FG, Gross KW, Watson G (1981) J Biol Chem 256:7006–7013
Berger FG, Loose DS, Meisner HM, Watson G (1986) Biochemistry 25: 1170–1175
Berger FG, Szymanski P, Read E, Watson G (1984) J Biol Chem 259:7941–7946
Bishop JO, Clark AJ, Clissold PM, Hainey S, Franke V (1982) EMBO J 1:615–620
Catterall JF, Kontula KK, Watson CS, Seppänen PJ, Funkenstein B, Melanitou E, Hickok NJ, Bardin CW, Jänne OA (1986) Recent Prog Horm Res 42:71–109
Choi JR, Scheffler IE (1983) J Biol Chem 258: 12601–12608
Clark AJ, Hickman J, Bishop JO (1984) EMBO J 3:2055–2064
Elliott RW, Berger FG (1983) Proc Natl Acad Sci USA 80:501–504
Field LJ, Gross KW (1985) Proc Natl Acad Sci USA 82:6196–6200
Fong WF, Heller JS, Canellakis ES (1976) Biochem Biophys Acta 428:456–465
Fujita K, Murakami Y, Hayashi S (1982) Biochem J 204:647–652
Gilmour SK, Avdalovic N, Madava T, O’Brien TG (1985) J Biol Chem 260:16439–16444
Gupta M, Coffino P (1985) J Biol Chem 260:2941–2944
Heby O, Jänne J (1981): In: Morris DR, Marton LJ (eds) Polyamines in Biology and Medicine. Marcel Dekker Inc, New York, pp 243–310
Heller JS, Fong WF, Canellakis ES (1976) Proc Natl Acad Sci USA 73: 1858–1862
Heller JS, Canellakis ES (1981) J Cell Physiol 107:209–217
Hickok NJ, Seppänen PJ, Kontula KK, Jänne PA, Bardin CW, Jänne OA (1986) Proc Natl Acad Sci USA 83:594–598
Isomaa V, Pajunen AEI, Bardin CW, Jänne OA (1982) Endocrinology 111:833–843
Isomaa VV, Pajunen AEI, Bardin CW, Jänne OA (1983) J Biol Chem 258:6735–6740
Jänne OA, Kontula KK, Isomaa VV, Bardin CW (1984) Ann NY Acad Sci 438:72–84
Jänne J, Pösö H, Raina A (1978) Biochim Biophys Acta 473:241–293
Kahana C, Nathans D (1984) Proc Natl Acad Sci USA 81:3645–3649
Kahana C, Nathans D (1985a) J Biol Chem 260:15390–15393
Kahana C, Nathans D (1985b) Proc Natl Acad Sci USA 82:1673–1677
King D, Snider LD, Lingrel JB (1986) Mol Cell Biol 6:209–217
Kitani T, Fujisawa H (1981) J Biol Chem 256:10036–10040
Kontula KK, Seppänen PJ, Van Duyne P, Bardin CW, Jänne OA (1985) Endocrinology 116:226–233
Kontula KK, Torkkeli TK, Bardin CW, Jänne OA (1984) Proc Natl Acad Sci USA 81:731–735
Kuhn NJ, Woodworth-Gutai M, Gross K, Held WA (1984) Nucl Acids Res 12:6073–6090
Loeb D, Houben PW, Bullock LP (1984) Mol Cell Endocrinol 38:67–73
McConlogue L, Gupta M, Wu L, Coffino P (1984) Proc Natl Acad Sci USA 81:540–544
McConlogue L, Coffino P (1983) J Biol Chem 258:8384–8388
Melanitou E, Cohn DA, Bardin CW, Jänne OA (1986) Mol Endocrinol, submitted for publication
Mitchell JLA, Wilson JM (1983) Biochem J 214:345–351
O’Malley BW, Means AR (1974) Science 183:610–620
O’Malley BW, Roop DR, Lai EC, Nordstrom JL, Catterall JF, Swaneck GE, Colbert DA, Tsai M-J, Dugaiczyk A, Woo SLC (1979) Recent Prog Horm Res 35:1–46
Pajunen AEI, Isomaa VV, Jänne OA, Bardin CW (1982) J Biol Chem 257:8190–8198
Palmer R, Gallagher PM, Boyko WL, Ganschow RE (1983) Proc Natl Acad Sci USA 80:7596–7600
Panthier J-J, Rougeon F (1983) EMBO J 2:675–678
Pegg AE, McCann PL (1982) Am J Physiol 243:C212-C221
Persson L (1981) Acta Chem Scand B35:451–459
Persson L, Seely JE, Pegg AE (1984) Biochemistry 23:3777–3783
Pohjanpelto P, Hölttä E, Jänne OA, Knuutila S, Alitalo K (1985) J Biol Chem 260:8532–8537
Russel DH (1981) Biochem Biophys Res Commun 99:1167–1172
Seely JE, Pösö H, Pegg AE (1982a) Biochemistry 21:3394–3399
Seely JE, Pösö H, Pegg AE (1982b) J Biol Chem 257:7549–7553
Seely JE, Pegg AE (1983) J Biol Chem 258:2496–2500
Seely JE, Persson L, Sertich GJ, Pegg AE (1985) Biochem J 226:577–586
Shapiro SZ, Young JR (1981) J Biol Chem 256:1495–1498
Swank RT, Paigen K, Davey R, Chapman V, Labarca C, Watson G, Ganschow R, Brandt EJ, Novak E (1978) Recent Prog Horm Res 34:401–436
Tabor CW, Tabor H (1984) Annu Rev Biochem 53:749–790
Tata JR, Smith DF (1979) Recent Prog Horm Res 35:47–95
Watson CS, Catterall JF (1986) Endocrinology 118:1081–1086
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag New York Inc.
About this paper
Cite this paper
Jänne, O.A., Hickok, N.J., Seppänen, P.J., Kontula, K.K., Melanitou, E., Bardin, C.W. (1987). Ornithine Decarboxylase mRNAs in Murine Kidney: Structure and Regulation by Androgens. In: Roy, A.K., Clark, J.H. (eds) Gene Regulation by Steroid Hormones III. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4686-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4686-2_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-9114-5
Online ISBN: 978-1-4612-4686-2
eBook Packages: Springer Book Archive