Abstract
In this chapter we describe data from cell enucleation experiments that indicate that the unoccupied estrogen receptor is a nuclear rather than a cytoplasmic protein. In the revised model for estrogen action (Fig. 1), the estrogen receptor is assumed to be a nuclear protein both before and after hormone binding. We also discuss other published work that is related to the proposition that the unoccupied estrogen receptor is a nuclear protein (reviewed in Welshons and Gorski, 1986) and that suggest a reevaluation of the translocation model of steroid action.
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Welshons, W.V., Cormier, E.M., Jordan, V.C., Gorski, J. (1987). Biochemical Evidence for the Exclusive Nuclear Localization of the Estrogen Receptor. In: Roy, A.K., Clark, J.H. (eds) Gene Regulation by Steroid Hormones III. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4686-2_1
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DOI: https://doi.org/10.1007/978-1-4612-4686-2_1
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