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A Quantitative Study of Substance P and Cholecystokinin Coexistence in Primary Afferent Axonal Varicosities in the Rat Spinal Cord

  • M. M. Tuchscherer
  • V. S. Seybold
Conference paper

Abstract

Recent data from our laboatory [l] demonstrated that substance P (SP) and cholecystokinin-octapeptide (CCK) immunoreactivity co-exist in some, but not all, primary afferent neurons in dorsal root ganglia of the rat. Furthermore, four populations of primary afferent perikarya could be distinguished on the basis of size, cytology and peptide content. Within the small dorsal root ganglion cells (cells 12–20 um in diameter), populations were described that contained SP or SP+CCK immunoreactivity. Within the range of intermediate-sized cells (cells 20–45 um in diameter), populations were described which were immunoreactive for CCK or CCK+SP.

Keywords

Dorsal Root Ganglion Primary Afferent Neuron Capsaicin Treatment Dorsal Root Ganglion Cell Dorsal Rhizotomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • M. M. Tuchscherer
    • 1
  • V. S. Seybold
    • 1
  1. 1.Department of Cell Biology and NeuroanatomyUniversity of MinnesotaMinneapolisUSA

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