A Quantitative Study of Substance P and Cholecystokinin Coexistence in Primary Afferent Axonal Varicosities in the Rat Spinal Cord

  • M. M. Tuchscherer
  • V. S. Seybold
Conference paper


Recent data from our laboatory [l] demonstrated that substance P (SP) and cholecystokinin-octapeptide (CCK) immunoreactivity co-exist in some, but not all, primary afferent neurons in dorsal root ganglia of the rat. Furthermore, four populations of primary afferent perikarya could be distinguished on the basis of size, cytology and peptide content. Within the small dorsal root ganglion cells (cells 12–20 um in diameter), populations were described that contained SP or SP+CCK immunoreactivity. Within the range of intermediate-sized cells (cells 20–45 um in diameter), populations were described which were immunoreactive for CCK or CCK+SP.


Dorsal Root Ganglion Primary Afferent Neuron Capsaicin Treatment Dorsal Root Ganglion Cell Dorsal Rhizotomy 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • M. M. Tuchscherer
    • 1
  • V. S. Seybold
    • 1
  1. 1.Department of Cell Biology and NeuroanatomyUniversity of MinnesotaMinneapolisUSA

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