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Substance K-, Substance P-, and Calcitonin Gene-Related Peptide-Immunoreactive Nerves in Female Reproductive Organs

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Substance P and Neurokinins

Abstract

Nerves in the female rat reproductive tract contain a number of neuropeptides in addition to catecholamines and acetylcholine; e.g., neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP) [1] and calcitonin generelated peptide (CGRP) [2]. Peptidecontaining nerves are perivascular, near the epithelium and in nonvascular smooth muscle. All of these substances are vasoactive and can influence nonvascular smooth musecle; some, such as SF, are in primary afferent nerves. Thus, these peptide-containing nerves could have important functions in the female reproductive system. In our continuing studies of the peripheral nervous system’s influence on reproductive tract function.we examined primary afferent nerves for other peptides besides SP; these include CGRP, cholecystokininoctapeptide (CCK-8), and substance K (SK, neurokinin A; hereafter referred to as NKA). We also examined the sensitivity of these nerves to capsaicin, a neurotoxin for primary sensory neurons.

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References

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Authors and Affiliations

  1. Department of Anatomy, University of Kentucky Medical School, Lexington, KY, 40536, USA

    R. E. Papka & H. H. Traurig

Authors
  1. R. E. Papka
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  2. H. H. Traurig
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Papka, R.E., Traurig, H.H. (1987). Substance K-, Substance P-, and Calcitonin Gene-Related Peptide-Immunoreactive Nerves in Female Reproductive Organs. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_77

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_77

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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