Substance K-, Substance P-, and Calcitonin Gene-Related Peptide-Immunoreactive Nerves in Female Reproductive Organs

  • R. E. Papka
  • H. H. Traurig
Conference paper


Nerves in the female rat reproductive tract contain a number of neuropeptides in addition to catecholamines and acetylcholine; e.g., neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP) [1] and calcitonin generelated peptide (CGRP) [2]. Peptidecontaining nerves are perivascular, near the epithelium and in nonvascular smooth muscle. All of these substances are vasoactive and can influence nonvascular smooth musecle; some, such as SF, are in primary afferent nerves. Thus, these peptide-containing nerves could have important functions in the female reproductive system. In our continuing studies of the peripheral nervous system’s influence on reproductive tract function.we examined primary afferent nerves for other peptides besides SP; these include CGRP, cholecystokininoctapeptide (CCK-8), and substance K (SK, neurokinin A; hereafter referred to as NKA). We also examined the sensitivity of these nerves to capsaicin, a neurotoxin for primary sensory neurons.


Vasoactive Intestinal Polypeptide Primary Afferent Nerve Calcitonin Gene Female Reproductive Organ Plasma Protein Extravasation 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • R. E. Papka
    • 1
  • H. H. Traurig
    • 1
  1. 1.Department of AnatomyUniversity of Kentucky Medical SchoolLexingtonUSA

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