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Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor

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Substance P and Neurokinins

Abstract

Neurogenic inflammation refers to the vasodilation and plasma extravasation (PE) that occurs following release of neuromodulators, including tachykinins, from capsaicin-sensitive nerves [1]. Substance P (SP) has been the most widely studied tachykinin, but recently it has been demonstrated that Neurokinins A (NKA) and B (NKB) are also present in the peripheral and central nervous systems, especially in unmyelinated nerves and dorsal horn of the spinal cord [2]. PE appears to be effected by tachykinins acting directly on post-capillary venules as well as through release of mast cell derived amines in rat skin [3].

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References

  1. White DM, Helme RD (1985) Release of substance P from peripheral nerve terminals following electrical nerve stimulation of the sciatic nerve. Brain Res 336:27–32

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Author information

Authors and Affiliations

  1. Department of Medicine, Prince Henry’s Hospital, Monash University, Melbourne, 3004, Australia

    P. V. Andrews & R. D. Helme

Authors
  1. P. V. Andrews
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  2. R. D. Helme
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Andrews, P.V., Helme, R.D. (1987). Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_67

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_67

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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