Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor
Neurogenic inflammation refers to the vasodilation and plasma extravasation (PE) that occurs following release of neuromodulators, including tachykinins, from capsaicin-sensitive nerves . Substance P (SP) has been the most widely studied tachykinin, but recently it has been demonstrated that Neurokinins A (NKA) and B (NKB) are also present in the peripheral and central nervous systems, especially in unmyelinated nerves and dorsal horn of the spinal cord . PE appears to be effected by tachykinins acting directly on post-capillary venules as well as through release of mast cell derived amines in rat skin .
KeywordsHistamine Cimetidine Capsaicin Mast Dermatol