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Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor

  • P. V. Andrews
  • R. D. Helme
Conference paper

Abstract

Neurogenic inflammation refers to the vasodilation and plasma extravasation (PE) that occurs following release of neuromodulators, including tachykinins, from capsaicin-sensitive nerves [1]. Substance P (SP) has been the most widely studied tachykinin, but recently it has been demonstrated that Neurokinins A (NKA) and B (NKB) are also present in the peripheral and central nervous systems, especially in unmyelinated nerves and dorsal horn of the spinal cord [2]. PE appears to be effected by tachykinins acting directly on post-capillary venules as well as through release of mast cell derived amines in rat skin [3].

Keywords

Dorsal Horn Wool Fabric Neurogenic Inflammation Plasma Extravasation Unmyelinated Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • P. V. Andrews
    • 1
  • R. D. Helme
    • 1
  1. 1.Department of Medicine, Prince Henry’s HospitalMonash UniversityMelbourneAustralia

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