Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor

  • P. V. Andrews
  • R. D. Helme
Conference paper


Neurogenic inflammation refers to the vasodilation and plasma extravasation (PE) that occurs following release of neuromodulators, including tachykinins, from capsaicin-sensitive nerves [1]. Substance P (SP) has been the most widely studied tachykinin, but recently it has been demonstrated that Neurokinins A (NKA) and B (NKB) are also present in the peripheral and central nervous systems, especially in unmyelinated nerves and dorsal horn of the spinal cord [2]. PE appears to be effected by tachykinins acting directly on post-capillary venules as well as through release of mast cell derived amines in rat skin [3].


Histamine Cimetidine Capsaicin Mast Dermatol 


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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • P. V. Andrews
    • 1
  • R. D. Helme
    • 1
  1. 1.Department of Medicine, Prince Henry’s HospitalMonash UniversityMelbourneAustralia

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