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Substance P Antagonists and Analgesia: Do They or Don’t They?

  • J. L. Vaught
  • R. Scott
  • H. I. Jacoby
Conference paper

Abstract

Substance P, an undecapeptide, is present in high concentrations in the dorsal horn of the spinal cord in thin afferent fibers (presumably C-fibers) associated with the transmission of noxious information [1,2]. Administered intrathecally, substance P has been reported to produce a transient hyperalgesia [3] and to induce behavioral responses suggested to be characteristic of noxious stimulation [4]. These pieces of evidence all support the suggestion that substance P has an excitatory role in neural transmission involving spinal nociceptive pathways.

Keywords

Analgesic Activity Agonistic Effect Morphine Sulfate Putative Substance Excitatory Role 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • J. L. Vaught
    • 1
  • R. Scott
    • 1
  • H. I. Jacoby
    • 1
  1. 1.Department of Biological ResearchMcNeil PharmaceuticalSpring HouseUSA

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