Substance P Antagonists and Analgesia: Do They or Don’t They?

  • J. L. Vaught
  • R. Scott
  • H. I. Jacoby
Conference paper


Substance P, an undecapeptide, is present in high concentrations in the dorsal horn of the spinal cord in thin afferent fibers (presumably C-fibers) associated with the transmission of noxious information [1,2]. Administered intrathecally, substance P has been reported to produce a transient hyperalgesia [3] and to induce behavioral responses suggested to be characteristic of noxious stimulation [4]. These pieces of evidence all support the suggestion that substance P has an excitatory role in neural transmission involving spinal nociceptive pathways.


Analgesic Activity Agonistic Effect Morphine Sulfate Putative Substance Excitatory Role 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • J. L. Vaught
    • 1
  • R. Scott
    • 1
  • H. I. Jacoby
    • 1
  1. 1.Department of Biological ResearchMcNeil PharmaceuticalSpring HouseUSA

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