Substance P Antagonists and Analgesia: Do They or Don’t They?
Substance P, an undecapeptide, is present in high concentrations in the dorsal horn of the spinal cord in thin afferent fibers (presumably C-fibers) associated with the transmission of noxious information [1,2]. Administered intrathecally, substance P has been reported to produce a transient hyperalgesia  and to induce behavioral responses suggested to be characteristic of noxious stimulation . These pieces of evidence all support the suggestion that substance P has an excitatory role in neural transmission involving spinal nociceptive pathways.
KeywordsAnalgesic Activity Agonistic Effect Morphine Sulfate Putative Substance Excitatory Role
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