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Endothelial-Dependent Binding of [125I]-Bolton-Hunter Substance P in Blood Vessels

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Substance P and Neurokinins

Abstract

Substance P is one of the most potent vasodilators known [1] and the vasodilatation in some dog, cat and rabbit arteries is endothelium-dependent [2]. Endothelium-dependent relaxation by Substance P has since been shown in rings of dog common carotid arteries [3], pig and dog coronary arteries [4] and in vivo in dog femoral artery [5]. This vasodilatation may be mediated by release of endothelium-derived relaxing factor (EDRF) [2]. In the study described here, we have used the techniques of in vitro radioligand binding and autoradiography [6] to detect the localization of [125I] Bolton-Hunter substance P (BHSP) to sections of blood vessels with the endothelium intact and to similar preparations with the endothelium removed.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Melbourne, Victoria, 3052, USA

    J. A. Stephenson & R. J. Summers

  2. Department of Biological and Health Sciences, Deakin University, Victoria, 3217, Australia

    E. Burcher

Authors
  1. J. A. Stephenson
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  2. R. J. Summers
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  3. E. Burcher
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Stephenson, J.A., Summers, R.J., Burcher, E. (1987). Endothelial-Dependent Binding of [125I]-Bolton-Hunter Substance P in Blood Vessels. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_19

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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