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Characterization of Binding of [125I]Iodohistidyl1-Substance K to Tachykinin K-Sites in Hamster Bladder

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Substance P and Neurokinins

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Abstract

P-type and K-type tachykinin binding sites exist in variable proportions in urinary bladder of different rodent species with hamster bladder containing predominantly high amounts of K-type sites [1; Burcher and Buck, this volume]. In the present report, 125iodohistidyl1-SK (ISK) has been employed as the radioligand to examine in detail the K-sites in hamster bladder.

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References

  1. Burcher, E, Buck, SH (1986) Multiple tachykinin binding sites in hamster, rat, and guinea-pig urinary bladder. Eur. J. Pharmacol., in press.

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  2. Burcher, E, Buck, SH, Lovenberg, W, O’Donohue, TL (1986) Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J. Pharmacol. Exp. Ther. 236 819–831.

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Author information

Authors and Affiliations

  1. Div. Biochemical Sci., Merrell Dow Res. Inst., Cincinnati, OH, USA

    S. H. Buck

Authors
  1. S. H. Buck
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Buck, S.H. (1987). Characterization of Binding of [125I]Iodohistidyl1-Substance K to Tachykinin K-Sites in Hamster Bladder. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_18

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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